PMID- 10746544
OWN - NLM
STAT- MEDLINE
DCOM- 20000615
LR  - 20191103
IS  - 1524-9557 (Print)
IS  - 1524-9557 (Linking)
VI  - 23
IP  - 2
DP  - 2000 Mar-Apr
TI  - Antitumor activity of interleukin-18 on mouse glioma cells.
PG  - 184-9
AB  - Interleukin-18 (IL-18) exhibits antitumor activity in various laboratory models. 
      In the current study, brain tumors in naive mice regressed after an intratumoral 
      injection of a single dose of recombinant IL-18 (rIL-18). Intraperitoneal rIL-18 
      substantially delayed the growth of subcutaneously inoculated gliomas but not 
      gliomas located in the brain. Efficacy was reduced when studies were performed in 
      mice depleted of natural killer cells. Although intracerebral administration of 
      rIL-18 increased the serum interferon-gamma concentration, the antitumor effect 
      of IL-18 was not mediated by interferon-gamma. These data suggest the therapeutic 
      potential for control of tumor growth by intratumoral administration of rIL-18 in 
      patients with glioma.
FAU - Kikuchi, T
AU  - Kikuchi T
AD  - Department of Oncology, The Institute of DNA Medicine, Jikei University School of 
      Medicine, Tokyo, Japan.
FAU - Akasaki, Y
AU  - Akasaki Y
FAU - Joki, T
AU  - Joki T
FAU - Abe, T
AU  - Abe T
FAU - Kurimoto, M
AU  - Kurimoto M
FAU - Ohno, T
AU  - Ohno T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Immunother
JT  - Journal of immunotherapy (Hagerstown, Md. : 1997)
JID - 9706083
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Growth Inhibitors)
RN  - 0 (Interleukin-18)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/immunology/*therapeutic use
MH  - Cell Survival/immunology
MH  - Glioma/*immunology/*therapy
MH  - Growth Inhibitors/immunology/therapeutic use
MH  - Injections, Intralesional
MH  - Injections, Intraperitoneal
MH  - Injections, Subcutaneous
MH  - Interleukin-18/administration & dosage/immunology/*pharmacology/therapeutic use
MH  - Killer Cells, Natural/immunology/metabolism
MH  - Mice
MH  - Mice, Inbred A
MH  - Recombinant Proteins/immunology/*therapeutic use
MH  - Stereotaxic Techniques
MH  - Tumor Cells, Cultured
EDAT- 2000/04/04 09:00
MHDA- 2000/06/17 09:00
CRDT- 2000/04/04 09:00
PHST- 2000/04/04 09:00 [pubmed]
PHST- 2000/06/17 09:00 [medline]
PHST- 2000/04/04 09:00 [entrez]
AID - 10.1097/00002371-200003000-00002 [doi]
PST - ppublish
SO  - J Immunother. 2000 Mar-Apr;23(2):184-9. doi: 10.1097/00002371-200003000-00002.