PMID- 10748298
OWN - NLM
STAT- MEDLINE
DCOM- 20000502
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 118
IP  - 2
DP  - 2000 Apr 15
TI  - Two cases of AML (M2) with a t(8;19)(q22;q13): a new cytogenetic variant.
PG  - 154-8
AB  - "Simple" variants of the t(8;21) translocation involving chromosome 8 and a 
      chromosome other than number 21 are rare. To our knowledge, only t(3;8)(q29;q22), 
      t(8;11)(q22;q13), t(8;16)(q22;q24), t(8;20)(q22;p13), and t(8;22) have been 
      reported in the literature. This paper describes for the first time two patients 
      with acute myelogenous leukemia with a consistent t(8;19)(q22;q13) translocation. 
      Their myelograms were compatible with the FAB-M2 subtype. The blasts from case 2 
      expressed CD34, CD33, CD13, and CD19. Karyotype analyses were performed on bone 
      marrow cells using R- and G-banding at presentation. A t(8;19)(q22;q13) 
      translocation was found in 28/30 metaphases for case 1 and in 23/25 metaphases 
      for case 2. The latter case also had a deletion of chromosome 9, del(9)(q12q22) 
      as an additional abnormality. Reverse transcriptase-polymerase chain reaction 
      study revealed no AML1/ETO fusion transcript in case 2. Dual-color fluorescence 
      in situ hybridization (FISH) assay using two probes (BAC92 and YAC412A4) 
      convincingly demonstrated that the chromosomal material from 8q was translocated 
      onto 19q rather than 19p in case 2. Thus, we consider t(8;19)(q22;q13) a true 
      "simple" variant of t(8;21), and assume that a fusion gene resulting from the 
      t(8;19) may contain the ETO gene located at 8q22 and an unknown partner gene from 
      19q13, which probably is a new transcription factor, whose molecular entity 
      warrants further study.
FAU - Xue, Y
AU  - Xue Y
AD  - Jiangsu Institute of Hematology, Leukemia Research Unit, First Affiliated 
      Hospital of Suzhou Medical College, Suzhou, People's Republic of China.
FAU - Niu, C
AU  - Niu C
FAU - Chen, S
AU  - Chen S
FAU - Wang, Y
AU  - Wang Y
FAU - Guo, Y
AU  - Guo Y
FAU - Xie, X
AU  - Xie X
FAU - Lu, D
AU  - Lu D
FAU - Li, P
AU  - Li P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adolescent
MH  - *Chromosomes, Human, Pair 19
MH  - *Chromosomes, Human, Pair 8
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Translocation, Genetic
EDAT- 2000/04/05 09:00
MHDA- 2000/05/08 09:00
CRDT- 2000/04/05 09:00
PHST- 2000/04/05 09:00 [pubmed]
PHST- 2000/05/08 09:00 [medline]
PHST- 2000/04/05 09:00 [entrez]
AID - S0165-4608(99)00185-5 [pii]
AID - 10.1016/s0165-4608(99)00185-5 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2000 Apr 15;118(2):154-8. doi: 
      10.1016/s0165-4608(99)00185-5.