PMID- 10751450
OWN - NLM
STAT- MEDLINE
DCOM- 20000515
LR  - 20191023
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 20
IP  - 8
DP  - 2000 Apr 15
TI  - Role of brain-derived neurotrophic factor in the circadian regulation of the 
      suprachiasmatic pacemaker by light.
PG  - 2978-87
AB  - The central pacemaker located in the suprachiasmatic nucleus (SCN) of the 
      hypothalamus mediates the generation of mammalian circadian rhythms, including an 
      oscillation in pacemaker sensitivity to photic signals conveyed by the 
      retinohypothalamic tract. Because brain-derived neurotrophic factor (BDNF) has 
      been implicated in the functional regulation of neural input to other targets of 
      visual pathways, the present study examined whether changes in BDNF expression or 
      blockade of its action in the SCN affect circadian pacemaker responses to light. 
      In rats receiving infusion of exogenous BDNF into the SCN, the free-running 
      rhythm of activity in constant darkness was characterized by large phase advances 
      in response to light exposure during the midsubjective day, when the circadian 
      pacemaker is normally insensitive to photic perturbation. In contrast, SCN 
      infusion of BDNF did not potentiate either phase-delaying or phase-advancing 
      effects of light on the rat activity rhythm during the subjective night. In 
      heterozygous BDNF mutant mice, deficits and damped rhythmicity in SCN levels of 
      this neurotrophin were accompanied by marked decreases in the amplitude of 
      light-induced phase shifts during the subjective night. In agreement with the 
      effects of decreased BDNF expression, SCN infusion of the tyrosine kinase 
      inhibitor K252a blocked or strongly inhibited both the phase-delaying and 
      -advancing effects of light during the subjective night. Collectively, these 
      findings suggest that BDNF-mediated signaling may play an important role in the 
      circadian regulation of SCN pacemaker sensitivity to light.
FAU - Liang, F Q
AU  - Liang FQ
AD  - Texas A&M University Health Science Center, Department of Human Anatomy, College 
      of Medicine, College Station, Texas 77843-1114, USA.
FAU - Allen, G
AU  - Allen G
FAU - Earnest, D
AU  - Earnest D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carbazoles)
RN  - 0 (Indole Alkaloids)
RN  - 97161-97-2 (staurosporine aglycone)
RN  - EC 2.7.11.13 (Protein Kinase C)
SB  - IM
MH  - Animals
MH  - Biological Clocks/*drug effects/physiology
MH  - Brain-Derived Neurotrophic Factor/genetics/*pharmacology
MH  - Carbazoles/pharmacology
MH  - Circadian Rhythm/*drug effects/physiology
MH  - Indole Alkaloids
MH  - *Light
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Mutant Strains
MH  - Protein Kinase C/antagonists & inhibitors
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Suprachiasmatic Nucleus/*drug effects/physiology
PMC - PMC6772211
EDAT- 2001/02/07 11:00
MHDA- 2001/02/07 11:01
PMCR- 2000/10/15
CRDT- 2001/02/07 11:00
PHST- 2001/02/07 11:00 [pubmed]
PHST- 2001/02/07 11:01 [medline]
PHST- 2001/02/07 11:00 [entrez]
PHST- 2000/10/15 00:00 [pmc-release]
AID - 4074 [pii]
AID - 10.1523/JNEUROSCI.20-08-02978.2000 [doi]
PST - ppublish
SO  - J Neurosci. 2000 Apr 15;20(8):2978-87. doi: 10.1523/JNEUROSCI.20-08-02978.2000.