PMID- 10751620
OWN - NLM
STAT- MEDLINE
DCOM- 20000504
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 448
IP  - 1
DP  - 2000 Mar 14
TI  - Yield of SCEs and translocations produced by 3 aminobenzamide in cultured Chinese 
      hamster cells.
PG  - 29-34
AB  - Different concentrations of 3-aminobenzamide (3AB), a strong inhibitor of 
      poly(ADP-ribose) polymerase (PARP), were used to study their effect on the 
      BrdU-substituted DNA of the Chinese hamster AA8 cell line. The frequencies of 
      sister chromatid exchanges (SCEs) and translocations were determined using the 
      fluorescence plus Giemsa (FPG) and fluorescence in situ hybridization (FISH) 
      techniques, respectively. The results indicate that 3AB effectively induced a 
      dose-dependent increase in the frequency of SCEs, but this enhancement in the 
      yield of SCEs was not paralleled by an increase in translocations. These results 
      are discussed in terms of the as yet poorly understood molecular mechanisms of 
      action of the enzyme PARP.
FAU - Dominguez, I
AU  - Dominguez I
AD  - Department of Cell Biology, Faculty of Biology, University of Sevilla, Avda. 
      Reina Mercedes 6, 41012, Sevilla, Spain.
FAU - Mateos, S
AU  - Mateos S
FAU - Cortes, F
AU  - Cortes F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 0 (Benzamides)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Poly(ADP-ribose) Polymerase Inhibitors)
RN  - 8J365YF1YH (3-aminobenzamide)
RN  - EC 2.4.2.30 (Poly(ADP-ribose) Polymerases)
RN  - G34N38R2N1 (Bromodeoxyuridine)
SB  - IM
MH  - Animals
MH  - Benzamides/*pharmacology
MH  - Bromodeoxyuridine/pharmacology
MH  - CHO Cells/drug effects
MH  - *Chromosome Aberrations
MH  - Cricetinae
MH  - Dose-Response Relationship, Drug
MH  - Enzyme Inhibitors/*pharmacology
MH  - Poly(ADP-ribose) Polymerase Inhibitors
MH  - Poly(ADP-ribose) Polymerases/metabolism
MH  - Sister Chromatid Exchange/*drug effects
MH  - Translocation, Genetic
EDAT- 2001/02/07 11:00
MHDA- 2001/02/07 11:01
CRDT- 2001/02/07 11:00
PHST- 2001/02/07 11:00 [pubmed]
PHST- 2001/02/07 11:01 [medline]
PHST- 2001/02/07 11:00 [entrez]
AID - S0027-5107(99)00228-6 [pii]
AID - 10.1016/s0027-5107(99)00228-6 [doi]
PST - ppublish
SO  - Mutat Res. 2000 Mar 14;448(1):29-34. doi: 10.1016/s0027-5107(99)00228-6.