PMID- 10752987
OWN - NLM
STAT- MEDLINE
DCOM- 20000803
LR  - 20190116
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 37
IP  - 3-4
DP  - 2000 Apr
TI  - Human herpesviruses in primary ocular lymphoma.
PG  - 361-5
AB  - Several human lymphotropic herpesviruses have been found in certain 
      lymphoproliferative disorders and implicated as possible etiologic factors or as 
      modulating elements of the diseases. To assess a possible association of the 
      human herpesviruses with lymphomas arising from mucosa-associated lymphoid tissue 
      (MALT), we evaluated the presence of four human herpesviruses, Epstein-Barr virus 
      (EBV), human herpesvirus 6 (HHV-6), HHV-7, and HHV-8, in the biopsied specimens 
      from 14 patients with primary ocular MALT lymphomas. EBV DNA sequences were 
      detected in four specimens by polymerase chain reaction (PCR), and four cases 
      were positive for HHV-6 DNA. In situ hybridization showed that three and two of 
      14 cases were positive for EBV mRNA and HHV-6 DNA, respectively. Neither HHV-7 
      nor HHV-8 sequences could be detected by PCR. These findings would stimulate 
      further investigation as to the involvement of these lymphotropic viruses in the 
      pathogenesis of a subset of low-grade primary ocular lymphomas.
FAU - Daibata, M
AU  - Daibata M
AD  - Department of Medicine, Kochi Medical School, Japan. daibatam@kochi-ms.ac.jp
FAU - Komatsu, T
AU  - Komatsu T
FAU - Taguchi, H
AU  - Taguchi H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
SB  - IM
MH  - Adult
MH  - Aged
MH  - Eye Neoplasms/*virology
MH  - Female
MH  - Herpesviridae/genetics/*isolation & purification
MH  - Herpesviridae Infections/*virology
MH  - Herpesvirus 4, Human/genetics/isolation & purification
MH  - Herpesvirus 6, Human/genetics/isolation & purification
MH  - Herpesvirus 7, Human/genetics/isolation & purification
MH  - Herpesvirus 8, Human/genetics/isolation & purification
MH  - Humans
MH  - In Situ Hybridization
MH  - Lymphoma, B-Cell/*virology
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Tumor Virus Infections/*virology
EDAT- 2000/04/07 09:00
MHDA- 2000/08/06 11:00
CRDT- 2000/04/07 09:00
PHST- 2000/04/07 09:00 [pubmed]
PHST- 2000/08/06 11:00 [medline]
PHST- 2000/04/07 09:00 [entrez]
AID - 10.3109/10428190009089436 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2000 Apr;37(3-4):361-5. doi: 10.3109/10428190009089436.