PMID- 10753856
OWN - NLM
STAT- MEDLINE
DCOM- 20000505
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 95
IP  - 8
DP  - 2000 Apr 15
TI  - The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the 
      BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse 
      large B-cell lymphoma.
PG  - 2719-21
AB  - The BCL6 gene, isolated from the breakpoints of 3q27-associated chromosomal 
      translocations, has been implicated in diffuse large B-cell lymphomas (DLBL). 
      Here we describe the molecular characterization of novel t(3;7)(q27;p12) 
      translocations in 2 patients with DLBL. Molecular genetic analysis of the 
      breakpoint area involving BCL6 revealed the presence of the Ikaros gene, a 
      central regulator of lymphoid differentiation that had been mapped to human 
      chromosome 7 band p13-p11.1. As a molecular consequence of the translocation, the 
      5' regulatory region of the BCL6 gene was replaced by the putative 5' regulatory 
      region of the Ikaros gene, probably leading to deregulated expression of the BCL6 
      gene throughout B-cell differentiation. Reverse transcription-polymerase chain 
      reaction (RT-PCR) and fluorescence in situ hybridization (FISH) analyses of a 
      patient sample established that the t(3;7)(q27;p12) results in fusion of the 
      Ikaros and BCL6 genes. This study provides the first evidence that the Ikaros 
      gene is rearranged in human hematopoietic malignant disorders. (Blood. 
      2000;95:2719-2721)
FAU - Hosokawa, Y
AU  - Hosokawa Y
AD  - Laboratory of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, 
      Japan. yhosokaw@aichi-cc.pref.aichi.jp
FAU - Maeda, Y
AU  - Maeda Y
FAU - Ichinohasama, R
AU  - Ichinohasama R
FAU - Miura, I
AU  - Miura I
FAU - Taniwaki, M
AU  - Taniwaki M
FAU - Seto, M
AU  - Seto M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (IKZF1 protein, human)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-bcl-6)
RN  - 0 (Transcription Factors)
RN  - 148971-36-2 (Ikaros Transcription Factor)
SB  - IM
MH  - Base Sequence
MH  - *Chromosomes, Human, Pair 3
MH  - *Chromosomes, Human, Pair 7
MH  - DNA-Binding Proteins/*genetics
MH  - Humans
MH  - Ikaros Transcription Factor
MH  - Lymphoma, B-Cell/*genetics
MH  - Lymphoma, Large B-Cell, Diffuse/*genetics
MH  - Molecular Sequence Data
MH  - Oncogene Proteins, Fusion
MH  - Proto-Oncogene Proteins/*genetics
MH  - Proto-Oncogene Proteins c-bcl-6
MH  - Transcription Factors/*genetics
MH  - *Translocation, Genetic
EDAT- 2001/02/07 11:00
MHDA- 2001/02/07 11:01
CRDT- 2001/02/07 11:00
PHST- 2001/02/07 11:00 [pubmed]
PHST- 2001/02/07 11:01 [medline]
PHST- 2001/02/07 11:00 [entrez]
AID - S0006-4971(20)64166-0 [pii]
PST - ppublish
SO  - Blood. 2000 Apr 15;95(8):2719-21.