PMID- 10754784
OWN - NLM
STAT- MEDLINE
DCOM- 20000525
LR  - 20190515
IS  - 1058-0468 (Print)
IS  - 1573-7330 (Electronic)
IS  - 1058-0468 (Linking)
VI  - 17
IP  - 1
DP  - 2000 Jan
TI  - The effects of age and abnormal sperm count on the nondisjunction of spermatozoa.
PG  - 51-9
AB  - PURPOSE: The effect of paternal age on the nondisjunction of sex chromosomes is 
      controversial. Also, the prevalence of chromosomal anomalies in infertile 
      patients is controversial, it has been reported that the sex chromosomal 
      aneuploidy rate following treatment with intracytoplasmic sperm injection (ICSI) 
      is higher than in naturally conceived pregnancies. We investigated the influence 
      of paternal age and oligozoospermia on the nondisjunction of spermatozoa. 
      METHODS: We determined the rate of aneuploidy for gonosomes and autosomes, using 
      two-color fluorescence in situ hybridization (FISH) of the X and Y chromosomes 
      and chromosomes 12 and 18 in 10 donors under 25 years of age who had a normal 
      sperm count (> or = 20 x 10(6)/ml), 10 donors over the age of 39 years with 
      idiopathic infertility and normozoospermia (> or = 20 x 10(6)/ml), and 5 
      oligozoospermic donors (< 20 x 10(6)/ml). RESULTS: There was no obvious 
      relationship between increasing age and autosomal disomy (disomy 12 and disomy 
      18). Neither autosomal disomy nor diploidy was increased in any group. The 
      frequency of X-, Y-, XX-, and YY-bearing sperm did not differ significantly among 
      groups, but the frequency of XY-bearing sperm was significantly higher in the 
      older infertile group than in the control donors. CONCLUSIONS: The incidence of 
      nondisjunction of paternal sex chromosome in meiosis I was higher in older men 
      with idiopathic infertility. The present results suggest that the risk of 
      producing XXY fetuses is higher among men > 39 years of age with idiopathic 
      infertility.
FAU - Asada, H
AU  - Asada H
AD  - Department of Obstetrics & Gynecology, Keio University School of Medicine, Tokyo, 
      Japan.
FAU - Sueoka, K
AU  - Sueoka K
FAU - Hashiba, T
AU  - Hashiba T
FAU - Kuroshima, M
AU  - Kuroshima M
FAU - Kobayashi, N
AU  - Kobayashi N
FAU - Yoshimura, Y
AU  - Yoshimura Y
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Assist Reprod Genet
JT  - Journal of assisted reproduction and genetics
JID - 9206495
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aneuploidy
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 12
MH  - Chromosomes, Human, Pair 18
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infertility, Male/*genetics
MH  - Male
MH  - Meiosis
MH  - Oligospermia/genetics/pathology
MH  - *Sperm Count
MH  - Spermatozoa/*physiology
MH  - X Chromosome
MH  - Y Chromosome
PMC - PMC3455190
EDAT- 2000/04/08 09:00
MHDA- 2000/06/08 09:00
PMCR- 2001/01/01
CRDT- 2000/04/08 09:00
PHST- 2000/04/08 09:00 [pubmed]
PHST- 2000/06/08 09:00 [medline]
PHST- 2000/04/08 09:00 [entrez]
PHST- 2001/01/01 00:00 [pmc-release]
AID - 221176 [pii]
AID - 10.1023/a:1009454114973 [doi]
PST - ppublish
SO  - J Assist Reprod Genet. 2000 Jan;17(1):51-9. doi: 10.1023/a:1009454114973.