PMID- 10755128
OWN - NLM
STAT- MEDLINE
DCOM- 20000504
LR  - 20161124
IS  - 0265-203X (Print)
IS  - 0265-203X (Linking)
VI  - 16
IP  - 9
DP  - 1999 Sep
TI  - Polymer additive migration to foods--a direct comparison of experimental data and 
      values calculated from migration models for high density polyethylene (HDPE).
PG  - 367-80
AB  - To reduce the amount of compliance testing for food contact polymers the use of 
      migration modelling has been proposed. This study was conducted to provide valid 
      data for the independent evaluation of two such diffusion-based models using a 
      range of different high density polyethylene (HDPE) polymers and plastics 
      additives. Seventy-two experimental migration data have been obtained in 
      triplicate and used to evaluate two Fickian-based migration models in the 
      prediction of specific migration of four HDPE additives into olive oil. All tests 
      were conducted using olive oil, representing the most severe case for fatty foods 
      with test conditions of 2 h at 70 degrees C, 6 h at 70 degrees C, 10 days at 40 
      degrees C representing short term exposures at high temperatures and room 
      temperature storage. Predicted migration values were calculated by inserting the 
      measured initial concentration of additive in the polymers (Cp,0) into the 
      equations together with known variables such as additive molecular weight, 
      temperature and exposure time. The results indicate that both models predict 
      migration values into olive oil close to, or in excess of, the experimental 
      results. The Piringer migration model, using the 'exact' calculations of the 
      Migratest Lite program, gave an overestimation for 83% of the migration values 
      generated in this study. The highest overestimation was 3.7 times the measured 
      value. For all measurements, the predicted migration from the Migratest Lite 
      program was greater than 50% of the observed value. The FDA model was found more 
      accurately to predict migration in most situations but underestimated migration 
      more frequently. Differences in the polymer specification had little effect on 
      specific migration of the additives investigated.
FAU - O'Brien, A
AU  - O'Brien A
AD  - Pira International, Surrey, UK.
FAU - Goodson, A
AU  - Goodson A
FAU - Cooper, I
AU  - Cooper I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Food Addit Contam
JT  - Food additives and contaminants
JID - 8500474
RN  - 0 (Plant Oils)
RN  - 9002-88-4 (Polyethylene)
SB  - IM
MH  - Chemical Phenomena
MH  - Chemistry, Physical
MH  - *Food Contamination
MH  - *Food Packaging
MH  - Humans
MH  - Models, Chemical
MH  - Plant Oils/chemistry
MH  - Polyethylene/*chemistry
EDAT- 2001/02/07 11:00
MHDA- 2001/02/07 11:01
CRDT- 2001/02/07 11:00
PHST- 2001/02/07 11:00 [pubmed]
PHST- 2001/02/07 11:01 [medline]
PHST- 2001/02/07 11:00 [entrez]
AID - 10.1080/026520399283858 [doi]
PST - ppublish
SO  - Food Addit Contam. 1999 Sep;16(9):367-80. doi: 10.1080/026520399283858.