PMID- 10755746
OWN - NLM
STAT- MEDLINE
DCOM- 20000427
LR  - 20190726
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 148
IP  - 3
DP  - 2000 Feb
TI  - Memory disturbances in "Ecstasy" users are correlated with an altered brain 
      serotonin neurotransmission.
PG  - 322-4
AB  - RATIONALE: Methylenedioxymethamphetamine (MDMA) is known to damage brain 
      pre-synaptic serotonin (5-HT) neurons. Since loss of 5-HT neurons has been 
      implicated in memory loss, it is important to establish whether MDMA use may 
      produce changes in postsynaptic 5-HT receptors and memory function in humans. 
      OBJECTIVES: To investigate whether MDMA use leads to compensative alterations in 
      post-synaptic 5-HT2A receptors and whether there is a relation with memory 
      disturbances. METHODS: Brain cortical 5-HT2A receptor densities were studied with 
      [123I]-5-I-R91150 SPECT in five abstinent MDMA users and nine healthy controls. 
      Memory performance was assessed using RAVLT. RESULTS: [123I]-5-I-R91150 binding 
      ratios were significantly higher in the occipital cortex of MDMA users than in 
      controls, indicating up-regulation. Mean cortical 5-HT2A receptor binding 
      correlated positively with RAVLT-recall in MDMA users. CONCLUSION: Our 
      preliminary results may indicate altered 5-HT neuronal function with correlated 
      memory impairment in abstinent MDMA users.
FAU - Reneman, L
AU  - Reneman L
AD  - Graduate School of Neurosciences, Department of Nuclear Medicine, Academic 
      Medical Center, Amsterdam, The Netherlands. l.reneman@amc.uva.nl
FAU - Booij, J
AU  - Booij J
FAU - Schmand, B
AU  - Schmand B
FAU - van den Brink, W
AU  - van den Brink W
FAU - Gunning, B
AU  - Gunning B
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Piperidines)
RN  - 0 (R 91150)
RN  - 0 (Receptor, Serotonin, 5-HT2A)
RN  - 0 (Receptors, Serotonin)
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Brain/*drug effects/metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Memory Disorders/*chemically induced
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects
MH  - Piperidines/metabolism
MH  - Receptor, Serotonin, 5-HT2A
MH  - Receptors, Serotonin/analysis
MH  - Serotonin/*metabolism
MH  - Synaptic Transmission/drug effects
MH  - Tomography, Emission-Computed, Single-Photon
EDAT- 2001/02/07 11:00
MHDA- 2001/02/07 11:01
CRDT- 2001/02/07 11:00
PHST- 2001/02/07 11:00 [pubmed]
PHST- 2001/02/07 11:01 [medline]
PHST- 2001/02/07 11:00 [entrez]
AID - 10.1007/s002130050057 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2000 Feb;148(3):322-4. doi: 10.1007/s002130050057.