PMID- 10756309
OWN - NLM
STAT- MEDLINE
DCOM- 20000823
LR  - 20220408
IS  - 0021-9304 (Print)
IS  - 0021-9304 (Linking)
VI  - 50
IP  - 4
DP  - 2000 Jun 15
TI  - Surface modification of poly(ethylene-co-vinyl alcohol) (EVA). Part I. 
      Introduction of carboxyl groups and immobilization of collagen.
PG  - 512-7
AB  - To enhance the surface biocompatibility of poly(ethylene-co-vinyl alcohol) (EVA) 
      and high-density polyethylene (HDPE), carboxyl groups were introduced by ozone 
      exposure. Type I collagen was immobilized onto the surface through polyion 
      complexing. The carboxyl groups on the EVA were characterized by electron 
      spectroscopy for chemical analysis and neutralization. The amounts of the 
      carboxylic group and collagen increased with increases in time and temperature of 
      exposure. Water-soluble fragments were produced by ozone exposure to EVA, and 
      they acted as collagen crosslinkers. The differences in charge distribution of 
      carboxyl groups affected the amount of collagen immobilization. Graft 
      polymerization of acrylic acid was also carried out onto EVA and HDPE surfaces. 
      The amount of collagen immobilized by graft polymerization was much higher than 
      that by ozone exposure despite the introduction of almost the same amounts of 
      carboxylic groups. It was suggested that the negative charge distribution 
      influences the amount of collagen immobilized onto films.
CI  - Copyright 2000 John Wiley & Sons, Inc.
FAU - Matsumura, K
AU  - Matsumura K
AD  - Institute for Frontier Medical Sciences, Kyoto University, Shogoin, Sakyo-Ku, 
      Kyoto 606-8507, Japan.
FAU - Hyon, S H
AU  - Hyon SH
FAU - Nakajima, N
AU  - Nakajima N
FAU - Peng, C
AU  - Peng C
FAU - Tsutsumi, S
AU  - Tsutsumi S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Biomed Mater Res
JT  - Journal of biomedical materials research
JID - 0112726
RN  - 0 (Biocompatible Materials)
RN  - 0 (Polyvinyls)
RN  - 25067-34-9 (ethylene-vinyl alcohol copolymer)
RN  - 66H7ZZK23N (Ozone)
RN  - 9002-88-4 (Polyethylene)
RN  - 9007-34-5 (Collagen)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - *Biocompatible Materials
MH  - *Collagen
MH  - Ozone
MH  - *Polyethylene
MH  - *Polyvinyls
MH  - Protein Binding
MH  - Surface Properties
MH  - Titanium
EDAT- 2000/04/11 09:00
MHDA- 2000/08/29 11:01
CRDT- 2000/04/11 09:00
PHST- 2000/04/11 09:00 [pubmed]
PHST- 2000/08/29 11:01 [medline]
PHST- 2000/04/11 09:00 [entrez]
AID - 10.1002/(SICI)1097-4636(20000615)50:4<512::AID-JBM6>3.0.CO;2-G [pii]
AID - 10.1002/(sici)1097-4636(20000615)50:4<512::aid-jbm6>3.0.co;2-g [doi]
PST - ppublish
SO  - J Biomed Mater Res. 2000 Jun 15;50(4):512-7. doi: 
      10.1002/(sici)1097-4636(20000615)50:4<512::aid-jbm6>3.0.co;2-g.