PMID- 10757511
OWN - NLM
STAT- MEDLINE
DCOM- 20000605
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 11
IP  - 4
DP  - 2000 Mar 20
TI  - Decreased GDNF mRNA expression in dorsal spinal cord of unilateral arthritic rat.
PG  - 737-41
AB  - It is now well established that nerve growth factor (NGF) plays a key role in 
      inflammation-induced hyperalgesia. It was also reported that brain derived 
      neurotrophic factor (BDNF), another member of neurotrophins, contributed to the 
      pain pathway as a neurotransmitter in the CNS. The present work demonstrated a 
      down-regulation of glial cell line-derived neurotrophic factor (GDNF) mRNA 
      expression in dorsal spinal cord in complete Freund's adjuvant-induced unilateral 
      arthritic rats serving as a chronic pain model. The fast occurring and long 
      lasting down-regulations suggest that GDNF might contribute to pain pathway in a 
      way different from neurotrophins and might play a role in the maintenance of 
      chronic pain status.
FAU - Fang, M
AU  - Fang M
AD  - Neuroscience Research Institute, Beijing Medical University, PR China.
FAU - Wang, Y
AU  - Wang Y
FAU - Liu, H X
AU  - Liu HX
FAU - Liu, X S
AU  - Liu XS
FAU - Han, J S
AU  - Han JS
LA  - eng
GR  - DA 03983/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (DNA Primers)
RN  - 0 (Gdnf protein, rat)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RNA, Messenger)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Arthritis, Experimental/*genetics/*metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - DNA Primers
MH  - Female
MH  - Functional Laterality
MH  - Glial Cell Line-Derived Neurotrophic Factor
MH  - Nerve Growth Factor/genetics
MH  - *Nerve Growth Factors
MH  - Nerve Tissue Proteins/*genetics
MH  - Posterior Horn Cells/*metabolism
MH  - RNA, Messenger/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Time Factors
EDAT- 2000/04/11 09:00
MHDA- 2000/06/10 09:00
CRDT- 2000/04/11 09:00
PHST- 2000/04/11 09:00 [pubmed]
PHST- 2000/06/10 09:00 [medline]
PHST- 2000/04/11 09:00 [entrez]
AID - 10.1097/00001756-200003200-00017 [doi]
PST - ppublish
SO  - Neuroreport. 2000 Mar 20;11(4):737-41. doi: 10.1097/00001756-200003200-00017.