PMID- 10758349
OWN - NLM
STAT- MEDLINE
DCOM- 20000512
LR  - 20190921
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 22
IP  - 2
DP  - 2000 Mar-Apr
TI  - Chronic ethanol exposure during late gestation produces behavioral anomalies in 
      neonatal lambs.
PG  - 205-12
AB  - A total of 45 pregnant ewes were assigned to one of three treatment groups: 1 g 
      ethanol/kg maternal body weight (n = 18); pair-fed control (n = 15); and ad lib 
      control (n = 12). Dosing started at gestational day (GD) 106, and was 
      administered every other day until GD 134. Parturition occurred between GD 144 
      and 147. Analysis of the placentas indicated that ethanol exposure decreased 
      cotyledon diameter and cotyledon weight compared to the control groups (p < 0. 
      05). At birth, lambs were given a Vigor Score and then behavior was assessed 
      using a videotape monitoring system for 24 h. Offspring in the ethanol treatment 
      group were significantly less vigorous at birth (p < 0.05). This finding reversed 
      during the subsequent 24 h such that the ethanol-exposed lambs were significantly 
      more active (p = 0.001) than the control lambs. Morphometric and histologic 
      examination of the cerebral cortex and hippocampus revealed no differences 
      amongst the three treatment groups. Collectively, the data demonstrate that 
      moderate ethanol exposure during the third-trimester equivalent of gestation can 
      produce placental dysmorphology and postnatal behavioral anomalies in neonatal 
      lambs in the absence of gross neurologic injury.
FAU - Spear-Smith, J
AU  - Spear-Smith J
AD  - Department of Animal Sciences, Purdue University, West Lafayette, IN, USA.
FAU - Brien, J F
AU  - Brien JF
FAU - Grafe, M
AU  - Grafe M
FAU - Allrich, R
AU  - Allrich R
FAU - Reynolds, J D
AU  - Reynolds JD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
SB  - IM
MH  - Abortion, Spontaneous
MH  - *Alcoholism
MH  - Animals
MH  - Animals, Newborn
MH  - Brain/*anatomy & histology/cytology
MH  - Cerebral Cortex/anatomy & histology/cytology
MH  - Female
MH  - Fetal Death
MH  - Gestational Age
MH  - Hippocampus/anatomy & histology/cytology
MH  - Litter Size
MH  - Mental Disorders/*etiology
MH  - *Motor Activity
MH  - Organ Size
MH  - Pregnancy
MH  - Pregnancy Complications
MH  - Pregnancy Outcome
MH  - *Prenatal Exposure Delayed Effects
MH  - Sheep
MH  - Videotape Recording
MH  - Weight Gain
EDAT- 2000/04/12 09:00
MHDA- 2000/05/20 09:00
CRDT- 2000/04/12 09:00
PHST- 2000/04/12 09:00 [pubmed]
PHST- 2000/05/20 09:00 [medline]
PHST- 2000/04/12 09:00 [entrez]
AID - S0892-0362(99)00059-8 [pii]
AID - 10.1016/s0892-0362(99)00059-8 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2000 Mar-Apr;22(2):205-12. doi: 
      10.1016/s0892-0362(99)00059-8.