PMID- 10758418
OWN - NLM
STAT- MEDLINE
DCOM- 20000606
LR  - 20211203
IS  - 0835-7900 (Print)
IS  - 0835-7900 (Linking)
VI  - 14
IP  - 3
DP  - 2000 Mar
TI  - Inflammatory bowel disease: progress toward a gene.
PG  - 207-18
AB  - The pathogenesis of ulcerative colitis (UC) and Crohn's disease (CD) is still 
      unknown, but the importance of genetic susceptibility has been clearly shown by 
      epidemiological data from family and twin studies. Linkage studies have 
      identified two susceptibility loci for inflammatory bowel disease (IBD) on 
      chromosomes 12 and 16. Importantly, these linkages have been replicated by 
      independent investigators, and studies of positional candidates within these 
      regions continue, together with fine mapping strategies. Regions of 'suggestive' 
      linkage on chromosomes 1, 3, 4, 6, 7, 10, 22 and X have also been reported in 
      individual studies. Other important candidate genes investigated include the 
      interleukin-1 receptor antagonist, MUC3 and genes of the human leukocyte antigen 
      (HLA) system. The apparently conflicting data in different studies from around 
      the world may be explained by ethnic differences, case mix and genetic 
      heterogeneity. Replicated class II HLA associations include HLA DRB1*0103 and DR2 
      (DRB1*1502), involved in UC susceptibility, and HLA DRB1*03 and DR4 as resistance 
      alleles for CD and UC respectively. Animal studies have provided insights from 
      targeted mutations and quantitative trait locus analysis. The goals of continuing 
      research include narrowing the regions of linkages and analysis of candidate 
      genes, and possibly the application of newly developed methods using single 
      nucleotide polymorphisms. Advances in IBD genetics hold the potential to provide 
      knowledge about the disease pathogenesis at the molecular level, with ensuing 
      benefits for clinical practice.
FAU - van Heel, D A
AU  - van Heel DA
AD  - Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom. 
      vanheel@well.ox.ac.uk
FAU - Satsangi, J
AU  - Satsangi J
FAU - Carey, A H
AU  - Carey AH
FAU - Jewell, D P
AU  - Jewell DP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Canada
TA  - Can J Gastroenterol
JT  - Canadian journal of gastroenterology = Journal canadien de gastroenterologie
JID - 8807867
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Animals
MH  - Chromosomes, Human, Pair 12
MH  - Chromosomes, Human, Pair 16
MH  - Cluster Analysis
MH  - Colitis, Ulcerative/*genetics
MH  - Crohn Disease/*genetics
MH  - Ethnicity/genetics
MH  - Genetic Linkage
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/genetics
MH  - Histocompatibility Antigens Class II/genetics
MH  - Humans
MH  - Polymorphism, Genetic
MH  - Twin Studies as Topic
RF  - 144
EDAT- 2000/04/12 09:00
MHDA- 2000/06/10 09:00
CRDT- 2000/04/12 09:00
PHST- 2000/04/12 09:00 [pubmed]
PHST- 2000/06/10 09:00 [medline]
PHST- 2000/04/12 09:00 [entrez]
AID - 10.1155/2000/361309 [doi]
PST - ppublish
SO  - Can J Gastroenterol. 2000 Mar;14(3):207-18. doi: 10.1155/2000/361309.