PMID- 10760298
OWN - NLM
STAT- MEDLINE
DCOM- 20000517
LR  - 20230331
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 97
IP  - 8
DP  - 2000 Apr 11
TI  - Brain-derived neurotrophic factor restores long-term potentiation in polysialic 
      acid-neural cell adhesion molecule-deficient hippocampus.
PG  - 4315-20
AB  - The neural cell adhesion molecule (NCAM) and its polysialylated form (PSA-NCAM) 
      contribute to long-term potentiation (LTP) in the CA1 hippocampus. Here we report 
      that the deficient LTP found in slices prepared from NCAM knockout mice and in 
      organotypic slice cultures treated with Endo-N, an enzyme that cleaves the PSA 
      moiety of NCAM, can be rescued by brain-derived neurotrophic factor (BDNF). This 
      effect is not reproduced by nerve growth factor, but can be obtained with high 
      concentrations of NT4/5. The effect of BDNF cannot be accounted for by 
      modifications of N-methyl-D-aspartate receptor-dependent responses or of 
      high-frequency bursts. PSA-NCAM, however, could directly interact with BDNF. 
      Exogenous application of PSA residues or recombinant PSA-NCAM also prevents LTP. 
      Furthermore trkB phosphorylation, and thus BDNF signaling, is reduced in both 
      NCAM knockout mice and Endo-N-treated slice cultures. These results suggest that 
      one action of PSA-NCAM could be to sensitize pyramidal neurons to BDNF, thereby 
      modulating activity-dependent synaptic plasticity.
FAU - Muller, D
AU  - Muller D
AD  - Neuropharmacology and Department of Morphology, Centre Medical Universitaire, 
      1211 Geneva 4, Switzerland. Dominique.Muller@medecine.unige.ch
FAU - Djebbara-Hannas, Z
AU  - Djebbara-Hannas Z
FAU - Jourdain, P
AU  - Jourdain P
FAU - Vutskits, L
AU  - Vutskits L
FAU - Durbec, P
AU  - Durbec P
FAU - Rougon, G
AU  - Rougon G
FAU - Kiss, J Z
AU  - Kiss JZ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20000321
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neural Cell Adhesion Molecules)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Culture Techniques
MH  - Hippocampus/metabolism/*physiology
MH  - Long-Term Potentiation/*physiology
MH  - Mice
MH  - Mice, Knockout
MH  - Neural Cell Adhesion Molecules/*genetics
MH  - Phosphorylation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/metabolism
PMC - PMC18239
EDAT- 2000/04/13 09:00
MHDA- 2000/05/20 09:00
PMCR- 2000/10/11
CRDT- 2000/04/13 09:00
PHST- 2000/04/13 09:00 [pubmed]
PHST- 2000/05/20 09:00 [medline]
PHST- 2000/04/13 09:00 [entrez]
PHST- 2000/10/11 00:00 [pmc-release]
AID - 97/8/4315 [pii]
AID - 070022697 [pii]
AID - 0226 [pii]
AID - 10.1073/pnas.070022697 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4315-20. doi: 10.1073/pnas.070022697. 
      Epub 2000 Mar 21.