PMID- 10760372
OWN - NLM
STAT- MEDLINE
DCOM- 20000815
LR  - 20190726
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 39
IP  - 7
DP  - 2000 Apr 27
TI  - Pituitary adenylate cyclase-activating polypeptide induces hyperthermia in the 
      rat.
PG  - 1303-8
AB  - The effects of centrally administered pituitary adenylate cyclase-activating 
      polypeptide (PACAP-38) on body temperature were investigated in rats. 
      Intracerebroventricular (i.c.v.) administration of PACAP-38 in doses of 500 and 
      1000 ng induced a dose-related elevation in colon temperature 2, 3, 4, 5 and 6 h 
      after injection. The i.c.v. pretreatment of the animals with different dilutions 
      of PACAP-38 antiserum prevented the development of hyperthermia in 
      PACAP-38-treated animals, whereas PACAP-38 antiserum alone did not modify the 
      colon temperature. An intramuscular injection of noraminophenazone (a 
      cyclooxygenase inhibitor) abolished the PACAP-38-induced hyperthermia. Our data 
      indicate that PACAP may induce hyperthermia via the central nervous system, and 
      this hyperthermic effect may be mediated via a cyclooxygenase-involved pathway.
FAU - Pataki, I
AU  - Pataki I
AD  - Department of Pathophysiology, Albert Szent-Gyorgyi Medical University, MTA-SZOTE 
      Neurohumoral Research Group, Semmelweis u. 1, PO Box 531, H-6701, Szeged, 
      Hungary.
FAU - Adamik, A
AU  - Adamik A
FAU - Jaszberenyi, M
AU  - Jaszberenyi M
FAU - Macsai, M
AU  - Macsai M
FAU - Telegdy, G
AU  - Telegdy G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Adcyap1 protein, rat)
RN  - 0 (Cyclooxygenase Inhibitors)
RN  - 0 (Neuropeptides)
RN  - 0 (Pituitary Adenylate Cyclase-Activating Polypeptide)
RN  - 01704YP3MO (Aminopyrine)
SB  - IM
MH  - Aminopyrine/pharmacology
MH  - Animals
MH  - Body Temperature/drug effects
MH  - Colon/drug effects/physiology
MH  - Cyclooxygenase Inhibitors/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Fever/*chemically induced/physiopathology
MH  - Injections, Intraventricular
MH  - Male
MH  - Neuropeptides/administration & dosage/antagonists & inhibitors/*pharmacology
MH  - Pituitary Adenylate Cyclase-Activating Polypeptide
MH  - Rats
MH  - Rats, Wistar
EDAT- 2000/04/13 09:00
MHDA- 2000/08/19 11:00
CRDT- 2000/04/13 09:00
PHST- 2000/04/13 09:00 [pubmed]
PHST- 2000/08/19 11:00 [medline]
PHST- 2000/04/13 09:00 [entrez]
AID - S0028390899002099 [pii]
AID - 10.1016/s0028-3908(99)00209-9 [doi]
PST - ppublish
SO  - Neuropharmacology. 2000 Apr 27;39(7):1303-8. doi: 10.1016/s0028-3908(99)00209-9.