PMID- 10760691
OWN - NLM
STAT- MEDLINE
DCOM- 20000508
LR  - 20190513
IS  - 0910-5050 (Print)
IS  - 1876-4673 (Electronic)
IS  - 0910-5050 (Linking)
VI  - 91
IP  - 3
DP  - 2000 Mar
TI  - Characterization of high-grade neuroendocrine tumors of the lung in relation to 
      menin mutations.
PG  - 317-23
AB  - It has been suggested that mutations in the menin gene play a role in the 
      development of multiple endocrine neoplasia type 1 (MEN1)-associated and of 
      sporadic forms of low- and intermediate-grade neuroendocrine tumors of the lung. 
      In the present study, eight tumor specimens of large cell neuroendocrine 
      carcinoma (LCNEC) and 13 of small cell lung cancer (SCLC), which represent a 
      high-grade category of neuroendocrine tumors, were examined for the potential 
      involvement of menin alterations as well as for the expression of various 
      neuroendocrine markers and p53 and Rb abnormalities. All specimens expressed 
      multiple neuroendocrine markers as expected and almost invariably carried p53 and 
      Rb alterations. Unexpectedly, however, mutations in the menin gene were not 
      detected in any of the high-grade neuroendocrine tumors examined. We thus 
      conclude that menin mutations do not play a crucial role in the pathogenesis of 
      high-grade subsets, in contrast to their suggested significant role in the 
      development of low- and intermediate-grade subsets. Interestingly, loss of 
      heterozygosity (LOH) in the menin gene appeared to be more prevalent in LCNEC 
      (50%) than in SCLC (22%), suggesting a possible distinction between SCLC and 
      LCNEC.
FAU - Haruki, N
AU  - Haruki N
AD  - Laboratory of Ultrastructure Research, Aichi Cancer Center Research Institute, 
      Chikusa-ku, Nagoya 464-8681, Japan.
FAU - Yatabe, Y
AU  - Yatabe Y
FAU - Travis, W D
AU  - Travis WD
FAU - Nomoto, S
AU  - Nomoto S
FAU - Osada, H
AU  - Osada H
FAU - Nakamura, S
AU  - Nakamura S
FAU - Nakao, A
AU  - Nakao A
FAU - Fujii, Y
AU  - Fujii Y
FAU - Takahashi, T
AU  - Takahashi T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jpn J Cancer Res
JT  - Japanese journal of cancer research : Gann
JID - 8509412
RN  - 0 (DNA Primers)
RN  - 0 (Genetic Markers)
RN  - 0 (MEN1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Carcinoma, Large Cell/*genetics
MH  - Carcinoma, Small Cell/*genetics
MH  - DNA Primers
MH  - Genes, Tumor Suppressor/*genetics
MH  - Genetic Markers
MH  - Humans
MH  - Lung Neoplasms/*genetics
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Neoplasm Proteins/*genetics
MH  - *Proto-Oncogene Proteins
PMC - PMC5926365
EDAT- 2000/04/13 09:00
MHDA- 2000/05/16 09:00
PMCR- 2000/03/01
CRDT- 2000/04/13 09:00
PHST- 2000/04/13 09:00 [pubmed]
PHST- 2000/05/16 09:00 [medline]
PHST- 2000/04/13 09:00 [entrez]
PHST- 2000/03/01 00:00 [pmc-release]
AID - CAE317 [pii]
AID - 10.1111/j.1349-7006.2000.tb00947.x [doi]
PST - ppublish
SO  - Jpn J Cancer Res. 2000 Mar;91(3):317-23. doi: 10.1111/j.1349-7006.2000.tb00947.x.