PMID- 10761215
OWN - NLM
STAT- MEDLINE
DCOM- 20000531
LR  - 20131121
IS  - 0042-8809 (Print)
IS  - 0042-8809 (Linking)
VI  - 45
IP  - 6
DP  - 1999 Nov-Dec
TI  - [The dynamic of biochemical stress reaction inductors in various tactics for 
      surgical treatment of patients with a combined trauma of cranium and lower limbs 
      ].
PG  - 494-500
AB  - In 31 patients after a craniocerebral trauma combined with a trauma of locomotor 
      system (CCCT), and in 28 patients with only a limb fractures a time course (1, 3, 
      7, and 14 days) of biochemical stress reaction inductors (cortisol, serotonin, 
      histamine, lipid peroxidation products) in various tactics of surgical treatment 
      was studied. It was established that CCCT in a significantly stronger degree 
      increases cortisol and lipid peroxidation products' levels than an isolated 
      locomotor system trauma. An early postponed surgical intervention in lower 
      extremities in CCCT results in the same increase in the biochemical stress 
      reaction inductors as a late postpone surgical intervention in the lower 
      extremities. In an early postponed osteosynthesis in CCCT patients, a mean term 
      of hospital stay was 67 days, and in a late postponed one 117 days. The 
      disability period was correspondingly 200 vs 315 days.
FAU - Lebedev, V V
AU  - Lebedev VV
AD  - N.V. Sklifosovsky Institute for Emergency Medicine, Moscow.
FAU - Golikov, P P
AU  - Golikov PP
FAU - Davydov, B V
AU  - Davydov BV
FAU - Rakhimi, K I
AU  - Rakhimi KI
FAU - Suvalian, A G
AU  - Suvalian AG
FAU - Nikolaeva, N Iu
AU  - Nikolaeva NIu
FAU - Fedorova, N V
AU  - Fedorova NV
FAU - Marchenko, V V
AU  - Marchenko VV
LA  - rus
PT  - English Abstract
PT  - Journal Article
TT  - Dinamika biokhimicheskikh induktorov stress-reaktsii pri razlichnoi taktike 
      khirurgicheskogo lecheniia bol'nykh s sochetannoi travmoi cherapa i nizhnikh 
      konechnostei.
PL  - Russia (Federation)
TA  - Vopr Med Khim
JT  - Voprosy meditsinskoi khimii
JID - 0416601
RN  - 333DO1RDJY (Serotonin)
RN  - 820484N8I3 (Histamine)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Craniocerebral Trauma/*blood/complications/physiopathology/surgery
MH  - Histamine/blood
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Leg Injuries/*blood/complications/physiopathology/surgery
MH  - Lipid Peroxidation
MH  - Serotonin/blood
MH  - Stress Disorders, Post-Traumatic/*blood
MH  - Surgical Procedures, Operative
EDAT- 2000/04/13 09:00
MHDA- 2000/06/03 09:00
CRDT- 2000/04/13 09:00
PHST- 2000/04/13 09:00 [pubmed]
PHST- 2000/06/03 09:00 [medline]
PHST- 2000/04/13 09:00 [entrez]
PST - ppublish
SO  - Vopr Med Khim. 1999 Nov-Dec;45(6):494-500.