PMID- 10761990
OWN - NLM
STAT- MEDLINE
DCOM- 20000621
LR  - 20191025
IS  - 0893-5785 (Print)
IS  - 0893-5785 (Linking)
VI  - 13
IP  - 1
DP  - 2000 Feb
TI  - The regulation of normal melanocyte proliferation.
PG  - 4-14
AB  - In vitro, normal human melanocytes require synergistic mitogens, in addition to 
      the common growth factors present in serum, in order to proliferate. The peptide 
      growth factors that confer stimulation are fibroblast growth factors (such as 
      bFGF/FGF2), hepatocyte growth factor/scatter factor (HGF/SF), mast/stem cell 
      factor (M/SCF), endothelins (such as ET-1) and melanotropin (MSH). The proper 
      function of these factors and their cognate receptors is likely to be important 
      in vivo, as all five ligands are produced in the skin, and disruption of their 
      normal function, by elimination due to deletions or mutations, or overproduction 
      due to ectopic expression, disrupts the normal distribution of melanocytes. The 
      synergistic growth factors activate intracellular signal transduction cascades 
      and maintain the intermediate effectors at optimal levels and duration required 
      for nuclear translocation and modification of transcription factors. The 
      consequent induction of immediate-early response genes, such as cyclins, and 
      subsequent activation of cyclin-dependent kinases (CDK4, CDK6 and CDK2) 
      inactivates the retinoblastoma family of proteins (pRb, p107 and p130, together 
      termed pocket proteins), and releases their suppressive association with E2F 
      transcription factors. Molecular events that disrupt this tight control of pocket 
      proteins and cause their inactivation, increase E2F transcriptional activity and 
      confer autonomous growth on melanocytes.
FAU - Halaban, R
AU  - Halaban R
AD  - Department of Dermatology, Yale University School of Medicine, New Haven, 
      Connecticut 06520-8059, USA. ruth.halaban@yale.edu
LA  - eng
GR  - CA44542/CA/NCI NIH HHS/United States
GR  - R01-AR39848/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Denmark
TA  - Pigment Cell Res
JT  - Pigment cell research
JID - 8800247
RN  - 0 (Growth Substances)
SB  - IM
MH  - Cell Division/drug effects/physiology
MH  - Cells, Cultured
MH  - Growth Substances/*pharmacology
MH  - Humans
MH  - Melanocytes/*cytology
MH  - Signal Transduction/drug effects/*physiology
RF  - 162
EDAT- 2000/04/13 09:00
MHDA- 2000/06/24 11:00
CRDT- 2000/04/13 09:00
PHST- 2000/04/13 09:00 [pubmed]
PHST- 2000/06/24 11:00 [medline]
PHST- 2000/04/13 09:00 [entrez]
AID - 10.1034/j.1600-0749.2000.130103.x [doi]
PST - ppublish
SO  - Pigment Cell Res. 2000 Feb;13(1):4-14. doi: 10.1034/j.1600-0749.2000.130103.x.