PMID- 10762369
OWN - NLM
STAT- MEDLINE
DCOM- 20000621
LR  - 20190815
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 12
IP  - 4
DP  - 2000 Apr
TI  - Trk B signalling controls LTP but not LTD expression in the developing rat visual 
      cortex.
PG  - 1411-9
AB  - Neurotrophins have been suggested to act as liaison molecules between 
      activity-dependent synaptic plasticity and the establishment of patterns of 
      synaptic connectivity during postnatal developmental in different brain areas, 
      including the visual cortex. In particular, recent studies have shown that Trk B 
      ligands are involved in the formation of the ocular dominance columns during 
      postnatal development. Here, we examined the contribution of endogenous Trk B 
      activation to the regulation of different forms of synaptic plasticity including 
      long-term potentiation (LTP), long-term depression (LTD) and LTP after LTD in the 
      developing visual cortex. Rat cortical slices were incubated with a soluble form 
      of Trk B receptor (TrkB IgG) preventing Trk B activation by endogenous ligands. 
      LTP expression was also studied at P23 (postnatal), when the expression of 
      brain-derived neurotrophic factor (BDNF) reaches a peak and the LTP expression is 
      normally downregulated. The present results demonstrate that Trk B activation is 
      required for the long-term maintenance, > 30 min, of both LTP and LTP after LTD 
      at P17. At P23, a higher concentration of TrkB IgG was necessary to impair LTP. 
      In contrast, neither amplitude nor duration of LTD were affected by Trk B ligands 
      blockade. Taken together, these results indicate that endogenous Trk B ligands 
      are necessary for the expression of LTP but not LTD at a critical time during 
      postnatal cortical development.
FAU - Sermasi, E
AU  - Sermasi E
AD  - International School for Advanced Studies (SISSA), Neuroscience Programme, Via 
      Beirut 2-4, 34014 Trieste, Italy.
FAU - Margotti, E
AU  - Margotti E
FAU - Cattaneo, A
AU  - Cattaneo A
FAU - Domenici, L
AU  - Domenici L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Nerve Growth Factors)
RN  - 145172-44-7 (neurotrophin 5)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal
MH  - Brain Chemistry/drug effects/physiology
MH  - Brain-Derived Neurotrophic Factor/pharmacology
MH  - Electrophysiology
MH  - Immunoglobulin G/pharmacology
MH  - Long-Term Potentiation/*physiology
MH  - Membrane Potentials/physiology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Nerve Growth Factors/pharmacology
MH  - Neural Inhibition/*physiology
MH  - Neuronal Plasticity/physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptor, trkB/analysis/immunology/*physiology
MH  - Visual Cortex/chemistry/*growth & development/*physiology
EDAT- 2000/04/13 09:00
MHDA- 2000/06/24 11:00
CRDT- 2000/04/13 09:00
PHST- 2000/04/13 09:00 [pubmed]
PHST- 2000/06/24 11:00 [medline]
PHST- 2000/04/13 09:00 [entrez]
AID - ejn014 [pii]
AID - 10.1046/j.1460-9568.2000.00014.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2000 Apr;12(4):1411-9. doi: 10.1046/j.1460-9568.2000.00014.x.