PMID- 10764021
OWN - NLM
STAT- MEDLINE
DCOM- 20000525
LR  - 20220311
IS  - 0815-9319 (Print)
IS  - 0815-9319 (Linking)
VI  - 15
IP  - 3
DP  - 2000 Mar
TI  - Gastro-oesophageal reflux disease in Asia.
PG  - 230-8
AB  - Gastro-oesophageal reflux disease (GORD) occurs more frequently in Europe and 
      North America than in Asia but its prevalence is now increasing in many Asian 
      countries. Many reasons have been given for the lower prevalence of GORD in Asia. 
      Low dietary fat and genetically determined factors, such as body mass index and 
      maximal acid output, may be important. Other dietary factors appear to be less 
      relevant. Increased intake of carbonated drinks or aggravating medicines may 
      influence the increasing rates of GORD in some Asian countries but no strong 
      evidence links other factors, such as the age of the population, smoking or 
      alcohol consumption, to GORD. The management of GORD in Asia is similar to that 
      in Europe and North America but the lower incidence of severe oesophagitis in 
      Asia may alter the approach slightly. Also, because Asians tend to develop 
      stomach cancer at an earlier age, endoscopy is used routinely at an earlier stage 
      of investigation. Gastro-oesophageal reflux disease is essentially a motility 
      disorder, so short-term management of the disease can usually be achieved using 
      prokinetic agents (or histamine (H2)-receptor antagonists). More severe and 
      recurrent GORD may require proton pump inhibitors (PPI) or a combination of 
      prokinetic agents and PPI. The choice of long-term treatment may be influenced by 
      the relative costs of prokinetic agents and PPI.
FAU - Goh, K L
AU  - Goh KL
AD  - Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, 
      Malaysia. klgoh@unimed.po.my
FAU - Chang, C S
AU  - Chang CS
FAU - Fock, K M
AU  - Fock KM
FAU - Ke, M
AU  - Ke M
FAU - Park, H J
AU  - Park HJ
FAU - Lam, S K
AU  - Lam SK
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
SB  - IM
MH  - Asia/epidemiology
MH  - Gastroesophageal Reflux/*epidemiology
MH  - Humans
MH  - Incidence
MH  - Prevalence
MH  - Risk Factors
RF  - 71
EDAT- 2000/04/14 09:00
MHDA- 2000/06/08 09:00
CRDT- 2000/04/14 09:00
PHST- 2000/04/14 09:00 [pubmed]
PHST- 2000/06/08 09:00 [medline]
PHST- 2000/04/14 09:00 [entrez]
AID - 10.1046/j.1440-1746.2000.02148.x [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2000 Mar;15(3):230-8. doi: 
      10.1046/j.1440-1746.2000.02148.x.