PMID- 10764335
OWN - NLM
STAT- MEDLINE
DCOM- 20000608
LR  - 20111117
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 161
IP  - 4 Pt 1
DP  - 2000 Apr
TI  - Analysis of HLA antigens in Mycobacterium avium-intracellulare pulmonary 
      infection.
PG  - 1368-71
AB  - Mycobacterium avium-intracellulare (MAI) pulmonary infection may occur in 
      subjects with no preexisting lung disease and no known immunodeficiency, showing 
      radiologically nodular bronchiectasis. There have remained some unresolved 
      problems in the pathogenesis of the disorder, including the predominance in 
      elderly women and the presence of not deteriorated or deteriorated disease. In 
      the present study, we examined whether immunogenetic susceptibility is present in 
      the disorder. We evaluated 64 cases of MAI disease and analyzed their short-term 
      natural history by assessing symptoms, sputum bacteriology, and chest computed 
      tomographic findings. The frequencies of human leukocyte antigen (HLA) alleles in 
      patients were compared with those in 100 healthy Japanese control subjects. We 
      assayed the HLA-A, -B, -C, -DR, and -DQ antigens serologically. Among 64 
      patients, 37 (35 females) did not show deterioration, whereas 27 (24 females) 
      showed deterioration after an interval of 30 +/- 15 mo. There was no significant 
      frequency of HLA-B and -C alleles in either group. In 37 not deteriorated 
      patients, DR-6 was positive in 14 (37.8%) patients but in only 16 (16%) control 
      subjects (p = 0.0061, odds ratio [OR] = 3.20). DQ-4 was positive in 10 (27.0%) 
      patients but in only 10 (10%) control subjects (p = 0. 0122, OR = 3.33). In 27 
      deteriorated patients, HLA-A26 was positive in 14 (51.9%) patients but in only 21 
      (21.0%) control subjects (p = 0.0015, OR = 4.05). MAI pulmonary infection with 
      nodular bronchiectasis shows two types of outcome, deteriorated and not 
      deteriorated. The subjects with A-26 antigen might indicate the deterioration of 
      MAI infection.
FAU - Kubo, K
AU  - Kubo K
AD  - Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan. 
      keishik@hsp.md.shinshu-u.ac.jp
FAU - Yamazaki, Y
AU  - Yamazaki Y
FAU - Hanaoka, M
AU  - Hanaoka M
FAU - Nomura, H
AU  - Nomura H
FAU - Fujimoto, K
AU  - Fujimoto K
FAU - Honda, T
AU  - Honda T
FAU - Ota, M
AU  - Ota M
FAU - Kamijou, Y
AU  - Kamijou Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ4 antigen)
RN  - 0 (HLA-DR6 Antigen)
SB  - IM
MH  - Aged
MH  - Bronchiectasis/*immunology/microbiology
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*analysis
MH  - HLA-DQ Antigens/analysis
MH  - HLA-DR6 Antigen/analysis
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Mycobacterium avium-intracellulare Infection/*immunology
EDAT- 2000/04/14 09:00
MHDA- 2000/06/10 09:00
CRDT- 2000/04/14 09:00
PHST- 2000/04/14 09:00 [pubmed]
PHST- 2000/06/10 09:00 [medline]
PHST- 2000/04/14 09:00 [entrez]
AID - 10.1164/ajrccm.161.4.9906094 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2000 Apr;161(4 Pt 1):1368-71. doi: 
      10.1164/ajrccm.161.4.9906094.