PMID- 10765045
OWN - NLM
STAT- MEDLINE
DCOM- 20000802
LR  - 20220318
IS  - 1420-8008 (Print)
IS  - 1420-8008 (Linking)
VI  - 11
IP  - 3
DP  - 2000 May-Jun
TI  - A 2-year follow-up of behavioural and psychological symptoms in Alzheimer's 
      disease.
PG  - 147-52
AB  - BACKGROUND: The aim was to examine the longitudinal occurrence and persistence of 
      behavioural and psychological symptoms of dementia (BPSD) in Alzheimer's disease 
      (AD). METHODS: Following 60 patients with mild to severe AD over a period of 2 
      years with annual evaluations, the prospective occurrence and persistence of BPSD 
      in AD were determined by using the Behavioural Abnormalities in AD Rating scale 
      (BEHAVE-AD). Clinical and demographic features of the AD patients were analysed 
      for their association with course features of these symptoms. RESULTS: All of the 
      60 AD patients experienced BPSD at some point during the 2-year period, 
      particularly agitation was present in every patient within this period. 2-year 
      persistence of BPSD in AD was frequently observed in patients with agitation and 
      with depressiveness, with less frequency in patients with anxiety and 
      aggressiveness, but not in patients with delusions or hallucinations. 2-year 
      persistent aggressiveness was associated with older age and more functional 
      impairment. More functional impairment was also related to 2-year non-persistent 
      hallucinations. CONCLUSIONS: Counselling AD patients and their families and 
      tailoring therapeutic strategies should take into account the different modi of 
      BPSD in AD occurring and persisting longitudinally and interacting with 
      functional disturbances.
CI  - Copyright 2000 S. Karger AG, Basel
FAU - Haupt, M
AU  - Haupt M
AD  - Psychiatrische Klinik der Heinrich-Heine-Universitat Dusseldorf, Deutschland.
FAU - Kurz, A
AU  - Kurz A
FAU - Janner, M
AU  - Janner M
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Dement Geriatr Cogn Disord
JT  - Dementia and geriatric cognitive disorders
JID - 9705200
SB  - IM
MH  - Aged
MH  - Aggression/*psychology
MH  - Alzheimer Disease/diagnosis/*psychology
MH  - Anxiety Disorders/*diagnosis/epidemiology/*etiology
MH  - Depressive Disorder/*diagnosis/epidemiology/*etiology
MH  - Follow-Up Studies
MH  - Hallucinations/*diagnosis/epidemiology
MH  - Humans
MH  - Neuropsychological Tests
MH  - Prevalence
MH  - Prospective Studies
MH  - Psychomotor Agitation/*diagnosis/epidemiology
MH  - Severity of Illness Index
EDAT- 2000/04/15 09:00
MHDA- 2000/08/06 11:00
CRDT- 2000/04/15 09:00
PHST- 2000/04/15 09:00 [pubmed]
PHST- 2000/08/06 11:00 [medline]
PHST- 2000/04/15 09:00 [entrez]
AID - 17228 [pii]
AID - 10.1159/000017228 [doi]
PST - ppublish
SO  - Dement Geriatr Cogn Disord. 2000 May-Jun;11(3):147-52. doi: 10.1159/000017228.