PMID- 10767321
OWN - NLM
STAT- MEDLINE
DCOM- 20000531
LR  - 20190513
IS  - 0964-6906 (Print)
IS  - 0964-6906 (Linking)
VI  - 9
IP  - 6
DP  - 2000 Apr 12
TI  - Untangling tau-related dementia.
PG  - 979-86
AB  - Abundant cytoplasmic inclusions consisting of aggregated hyperphosphorylated 
      protein tau are a characteristic pathological observation in several 
      neurodegenerative disorders such as Alzheimer's disease, Pick's disease, 
      frontotemporal dementia, cortico-basal degeneration and progressive supranuclear 
      palsy. The recent finding that mutations in the tau gene are responsible for 
      frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) has 
      provided convincing evidence that tau protein plays a key role in 
      neurodegeneration. In the short period since the identification of pathogenic 
      mutations in tau, remarkable progress has been made in understanding some of the 
      mechanisms by which these mutations lead to neurodegeneration. Understanding the 
      disease processes will hopefully provide us with new leads in developing 
      effective therapies for dementia.
FAU - Heutink, P
AU  - Heutink P
AD  - Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands. 
      heutink@kgen.fgg.eur.nl
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Hum Mol Genet
JT  - Human molecular genetics
JID - 9208958
RN  - 0 (tau Proteins)
SB  - IM
MH  - Dementia/genetics
MH  - Frontal Lobe/pathology
MH  - Genotype
MH  - Mutation
MH  - Phenotype
MH  - Temporal Lobe/pathology
MH  - tau Proteins/*genetics
RF  - 76
EDAT- 2000/04/18 09:00
MHDA- 2000/06/03 09:00
CRDT- 2000/04/18 09:00
PHST- 2000/04/18 09:00 [pubmed]
PHST- 2000/06/03 09:00 [medline]
PHST- 2000/04/18 09:00 [entrez]
AID - ddd099 [pii]
AID - 10.1093/hmg/9.6.979 [doi]
PST - ppublish
SO  - Hum Mol Genet. 2000 Apr 12;9(6):979-86. doi: 10.1093/hmg/9.6.979.