PMID- 10768736
OWN - NLM
STAT- MEDLINE
DCOM- 20000629
LR  - 20191103
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 11
IP  - 1
DP  - 2000 Feb
TI  - A new dipstick test (Allergodip) for in vitro diagnosis of latex 
      allergy--validation in patients with spina bifida.
PG  - 56-9
AB  - While there is established data on the value of various assays for determining 
      specific immunoglobulin E (IgE) in serum, little has been reported about 
      semi-quantitative dipstick methods. Therefore, in a pilot study we compared a new 
      dipstick assay (Allergodip) with a well-evaluated commercial assay (Pharmacia 
      CAP-system), in terms of sensitivity and specificity, in sensitized and 
      nonsensitized, symptomatic and non-symptomatic patients with spina bifida. 
      One-hundred and thirty-five patients with spina bifida (median age 10.8 years) 
      were included in this study. Sixty-nine patients (51.1%) were positive in the 
      CAP-system, 61 patients (45.2%) were positive in the Allergodip assay, and 67 
      patients (49.6%) were positive in a skin prick test with natural rubber latex 
      milk. The concordance between the CAP-system and Allergodip was good. Forty-seven 
      patients (34.8%) showed a positive response to the provocation test. The 
      sensitivity of Allergodip was 85.1% compared with 91.5% for the CAP-system. 
      Specificity was 75.0% for the Allergodip assay and 70.5% for the CAP-system. We 
      conclude that the new dipstick test is a useful screening test for diagnosing 
      sensitization to latex, e.g. when planning surgical interventions. However, in 
      instances of doubtful reactions, discrepancies with clinical features or for 
      scientific work it does not replace quantitative determination of specific IgE.
FAU - Niggemann, B
AU  - Niggemann B
AD  - University Children's Hospital Charite of Humboldt University, Berlin, Germany.
FAU - Wahn, U
AU  - Wahn U
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Reagent Kits, Diagnostic)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Latex Hypersensitivity/blood/*diagnosis
MH  - Male
MH  - Pilot Projects
MH  - *Reagent Kits, Diagnostic
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Skin Tests
MH  - Spinal Dysraphism/blood/*immunology
EDAT- 2000/04/18 09:00
MHDA- 2000/07/06 11:00
CRDT- 2000/04/18 09:00
PHST- 2000/04/18 09:00 [pubmed]
PHST- 2000/07/06 11:00 [medline]
PHST- 2000/04/18 09:00 [entrez]
AID - 10.1111/j.1399-3038.2000.00055.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2000 Feb;11(1):56-9. doi: 
      10.1111/j.1399-3038.2000.00055.x.