PMID- 10768999
OWN - NLM
STAT- MEDLINE
DCOM- 20000613
LR  - 20231213
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 68
IP  - 5
DP  - 2000 May
TI  - Interaction of Salmonella enterica serotype Typhimurium with dendritic cells is 
      defined by targeting to compartments lacking lysosomal membrane glycoproteins.
PG  - 2985-91
AB  - Dendritic cells (DCs) play a central role in the generation of acquired immunity 
      to infections by pathogenic microorganisms. Salmonella enterica serotype 
      Typhimurium is known to survive and proliferate intracellularly within 
      macrophages and nonphagocytic cells, but no data exist on how this pathogen 
      interacts with DCs. In this report, we show the capacity of serotype Typhimurium 
      to survive within the established mouse DC line CB1. In contrast to the case for 
      the macrophage model, the compartments of DCs containing serotype Typhimurium are 
      devoid of lysosomal membrane glycoproteins and the PhoPQ two-component regulatory 
      system is not essential for pathogen intracellular survival.
FAU - Garcia-Del Portillo, F
AU  - Garcia-Del Portillo F
AD  - Centro de Biologia Molecular "Severo Ochoa," Universidad Autonoma de Madrid-CSIC, 
      Cantoblanco, 28049 Madrid, Spain. fgportillo@cbm.uam.es
FAU - Jungnitz, H
AU  - Jungnitz H
FAU - Rohde, M
AU  - Rohde M
FAU - Guzman, C A
AU  - Guzman CA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Antigens, CD)
RN  - 0 (Bacterial Proteins)
RN  - 0 (Lysosomal Membrane Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (PhoQ protein, Bacteria)
RN  - 125360-99-8 (PhoP protein, Bacteria)
SB  - IM
MH  - Animals
MH  - Antigens, CD/*metabolism
MH  - Bacterial Proteins/genetics/*metabolism
MH  - Cell Compartmentation
MH  - Cell Line
MH  - Dendritic Cells/metabolism/*microbiology/ultrastructure
MH  - Lysosomal Membrane Proteins
MH  - Membrane Glycoproteins/*metabolism
MH  - Mice
MH  - Salmonella enterica/genetics/growth & development/*metabolism
MH  - Serotyping
PMC - PMC97514
EDAT- 2000/04/18 09:00
MHDA- 2000/06/17 09:00
PMCR- 2000/05/01
CRDT- 2000/04/18 09:00
PHST- 2000/04/18 09:00 [pubmed]
PHST- 2000/06/17 09:00 [medline]
PHST- 2000/04/18 09:00 [entrez]
PHST- 2000/05/01 00:00 [pmc-release]
AID - 1765 [pii]
AID - 10.1128/IAI.68.5.2985-2991.2000 [doi]
PST - ppublish
SO  - Infect Immun. 2000 May;68(5):2985-91. doi: 10.1128/IAI.68.5.2985-2991.2000.