PMID- 10769812
OWN - NLM
STAT- MEDLINE
DCOM- 20000706
LR  - 20061103
IS  - 0024-7766 (Print)
IS  - 0024-7766 (Linking)
VI  - 33
IP  - 1
DP  - 2000 Mar
TI  - Effect of complex decongestive physiotherapy on gene expression for the 
      inflammatory response in peripheral lymphedema.
PG  - 19-23
AB  - Complex decongestive physiotherapy (CDP), consisting of manual lymph drainage, 
      compression bandaging, remedial exercises and skin care, mobilizes accumulated 
      edema fluid and increases lymph flow. On the other hand, it also has a beneficial 
      therapeutic effect on fibrosclerosis. Because little is known of its possible 
      mode of action on a molecular level, this preliminary study evaluated CDP in 
      patients with peripheral leg lymphedema as to the potential role of gene 
      expression in the inflammatory response. The quantitative expression of genes for 
      CD14, interferon-gamma receptor (IFN gamma R), tumor necrosis factor-alpha (TNF 
      alpha), integrin alpha 4 beta 1 (VLA-4), tumor necrosis factor receptor p55 
      (TNFR1) and CD44 (standard form) was examined in 9 patients with primary or 
      secondary leg lymphedema before and after phase 1 of CDP. Overall, there was a 
      decrease of expression of these pro-inflammatory genes after CDP, suggesting that 
      biologic mechanisms implicated in the inflammatory cascades in other disorders 
      are also involved in the fibrosclerotic reactivity in lymphedema. However, 
      whereas each patient acted as his or her own control before and after CDP, gene 
      expression in normal patients and normal limbs before and after CDP needs to be 
      examined before the full meaning of these observations can be understood.
FAU - Foldi, E
AU  - Foldi E
AD  - Foldiklinik for Lymphology, Beiersdorf AG, Hamburg, Germany.
FAU - Sauerwald, A
AU  - Sauerwald A
FAU - Hennig, B
AU  - Hennig B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Lymphology
JT  - Lymphology
JID - 0155112
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Female
MH  - Gene Expression/physiology
MH  - Humans
MH  - Inflammation Mediators/*physiology
MH  - Lymphedema/immunology/*rehabilitation
MH  - Male
MH  - Middle Aged
MH  - *Physical Therapy Modalities
MH  - Polymerase Chain Reaction
EDAT- 2000/04/19 09:00
MHDA- 2000/07/08 11:00
CRDT- 2000/04/19 09:00
PHST- 2000/04/19 09:00 [pubmed]
PHST- 2000/07/08 11:00 [medline]
PHST- 2000/04/19 09:00 [entrez]
PST - ppublish
SO  - Lymphology. 2000 Mar;33(1):19-23.