PMID- 10771203
OWN - NLM
STAT- MEDLINE
DCOM- 20000901
LR  - 20190831
IS  - 0378-8741 (Print)
IS  - 0378-8741 (Linking)
VI  - 70
IP  - 2
DP  - 2000 May
TI  - The stem of sinomenium acutum inhibits mast cell-mediated anaphylactic reactions 
      and tumor necrosis factor-alpha production from rat peritoneal mast cells.
PG  - 135-41
AB  - The aqueous extract of Sinomenium acutum stem (SSAE) (0.1-1000 mg/kg) 
      dose-dependently inhibited systemic anaphylactic reaction induced by compound 
      48/80 in mice. In particular, SSAE reduced compound 48/80-induced anaphylactic 
      reaction with 50% at the dose of 1000 mg/kg. SSAE (100-1000 mg/kg) also 
      significantly inhibited local anaphylactic reaction activated by 
      anti-dinitrophenyl (DNP) IgE. When mice were pretreated with SSAE at a 
      concentration ranging from 0.1 to 1000 mg/kg, the plasma histamine levels were 
      reduced in a dose-dependent manner. SSAE (1-1000 microg/ml) dose-dependently 
      inhibited histamine release from the rat peritoneal mast cells (RPMCs) activated 
      by compound 48/80 or anti-DNP IgE. In addition, SSAE (0.1 microg/ml) had a 
      significant inhibitory effect on anti-DNP IgE-induced tumor necrosis factor-alpha 
      (TNF-alpha) production. These results indicate that SSAE inhibits mast 
      cell-mediated anaphylactic reactions and TNF-alpha production from mast cells.
FAU - Kim, H M
AU  - Kim HM
AD  - Department of Oriental Pharmacy, College of Pharmacy and Center of Oriental 
      Medicinal Science, Wonkwang University, Iksan, Chonbuk, South Korea. 
      hmkim@wonnms.wonkwang.ac.kr
FAU - Moon, P D
AU  - Moon PD
FAU - Chae, H J
AU  - Chae HJ
FAU - Kim, H R
AU  - Kim HR
FAU - Chung, J G
AU  - Chung JG
FAU - Kim, J J
AU  - Kim JJ
FAU - Lee, E J
AU  - Lee EJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
SB  - IM
MH  - Anaphylaxis/*prevention & control
MH  - Animals
MH  - Histamine Release/drug effects
MH  - Immunoglobulin E/immunology
MH  - Korea
MH  - Male
MH  - Mast Cells/*drug effects/physiology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Peritoneum/cytology
MH  - *Plants, Medicinal
MH  - Rats
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha/*antagonists & inhibitors/biosynthesis
MH  - p-Methoxy-N-methylphenethylamine/pharmacology
EDAT- 2000/04/20 09:00
MHDA- 2000/09/09 11:01
CRDT- 2000/04/20 09:00
PHST- 2000/04/20 09:00 [pubmed]
PHST- 2000/09/09 11:01 [medline]
PHST- 2000/04/20 09:00 [entrez]
AID - S0378-8741(99)00160-9 [pii]
AID - 10.1016/s0378-8741(99)00160-9 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2000 May;70(2):135-41. doi: 10.1016/s0378-8741(99)00160-9.