PMID- 10772486
OWN - NLM
STAT- MEDLINE
DCOM- 20000613
LR  - 20190513
IS  - 0891-6640 (Print)
IS  - 0891-6640 (Linking)
VI  - 14
IP  - 2
DP  - 2000 Mar-Apr
TI  - Frequency of pulmonary mineralization and hypoxemia in 21 dogs with 
      pituitary-dependent hyperadrenocorticism.
PG  - 151-6
AB  - The purpose of this study was to determine the frequency of hypoxemia and 
      pulmonary mineralization using 99mTc-methylene diphosphonate (99mTc-MDP) in dogs 
      with pituitary-dependent hyperadrenocorticism (PDH). Twenty-one dogs with PDH 
      were prospectively evaluated using thoracic radiography, arterial blood gas 
      analysis, and bone phase and pulmonary perfusion scintigraphy (using 
      99mTc-macro-aggregated albumin [99mTc-MAA]). The radiographs and bone and 
      perfusion studies were evaluated subjectively. An averaged quantitative count 
      density ratio was calculated between the thorax and cranial thoraco-lumbar 
      vertebrae from lateral thoracic 99mTc-MDP images. Thoracic:vertebral ratios were 
      calculated using 99mTc-MDP studies from 21 control dogs. The thoracic:vertebral 
      ratios were compared between the 2 groups (PDH and control). The mean age (+/-SD) 
      of the 21 PDH dogs was 10.2 (+/-3) years, whereas the mean age of the control 
      group was 9.8 (+/-3) years. Seven of the 21 dogs with PDH were hypoxemic (defined 
      as an arterial partial pressure of oxygen [PaO2] < 80 mm Hg) with an average PaO2 
      (+/-SD) of 62 (+/-15) mm Hg. Of the 7 hypoxemic dogs, 2 were found to have 
      pulmonary mineralization based on bone scintigraphic images. Pulmonary perfusion 
      abnormalities were not identified using 99mTc-MAA in any of the 21 PDH dogs. Six 
      PDH dogs had an abnormal interstitial pulmonary pattern and 5 of these dogs were 
      hypoxemic. The average quantitative thoracic:vertebral ratio was not 
      significantly different between the PDH and control dogs (0.5 +/- 0.4 versus 0.4 
      +/- 0.1, P = .16). Causes of hypoxemia other than pulmonary thromboembolism 
      should be considered in dogs with PDH. Pulmonary mineralization may contribute to 
      hypoxemia in dogs with PDH.
FAU - Berry, C R
AU  - Berry CR
AD  - Department of Anatomy, Physiological Sciences and Radiology, North Carolina State 
      University, College of Veterinary Medicine, Raleigh, USA. bkberry@iol15.com
FAU - Hawkins, E C
AU  - Hawkins EC
FAU - Hurley, K J
AU  - Hurley KJ
FAU - Monce, K
AU  - Monce K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Vet Intern Med
JT  - Journal of veterinary internal medicine
JID - 8708660
RN  - 0 (Minerals)
RN  - X89XV46R07 (Technetium Tc 99m Medronate)
SB  - IM
MH  - Adrenal Cortex Diseases/complications/diagnostic imaging/*veterinary
MH  - Animals
MH  - Dog Diseases/diagnostic imaging/*physiopathology
MH  - Dogs
MH  - Female
MH  - Hypoxia/etiology/*veterinary
MH  - Lung Diseases, Interstitial/diagnostic imaging/*veterinary
MH  - Male
MH  - Minerals/*metabolism
MH  - Pituitary Diseases/diagnostic imaging/*veterinary
MH  - Pulmonary Embolism/diagnosis/veterinary
MH  - Radionuclide Imaging
MH  - Technetium Tc 99m Medronate
EDAT- 2000/04/20 09:00
MHDA- 2000/06/17 09:00
CRDT- 2000/04/20 09:00
PHST- 2000/04/20 09:00 [pubmed]
PHST- 2000/06/17 09:00 [medline]
PHST- 2000/04/20 09:00 [entrez]
AID - 10.1892/0891-6640(2000)014<0151:fopmah>2.3.co;2 [doi]
PST - ppublish
SO  - J Vet Intern Med. 2000 Mar-Apr;14(2):151-6. doi: 
      10.1892/0891-6640(2000)014<0151:fopmah>2.3.co;2.