PMID- 10773738
OWN - NLM
STAT- MEDLINE
DCOM- 20000621
LR  - 20171101
IS  - 0300-5526 (Print)
IS  - 0300-5526 (Linking)
VI  - 43
IP  - 1
DP  - 2000
TI  - An arthrogenic alphavirus induces monocyte chemoattractant protein-1 and 
      interleukin-8.
PG  - 55-60
AB  - Cytokines and chemokines play important roles in both autoimmune and infectious 
      arthritides. Here we describe the cytokines and chemokines induced by Ross River 
      (RR) virus infection of synovial fibroblasts and macrophages in vitro. RR virus 
      is the aetiological agent of epidemic polyarthritis (EPA), a principally acute 
      and chronic rheumatic disease affecting up to 7,000 Australians annually. 
      Infected fibroblasts increased expression of mRNA coding for monocyte 
      chemoattractant protein-1 (MCP-1), interleukin-8 (IL-8), and 
      granulocyte-macrophage colony-stimulating factor. MCP-1, IL-8, macrophage 
      inflammatory protein-2, and to a lesser extent interferon gamma-induced 
      protein-10 mRNA were upregulated in infected macrophages. Expression of MCP-1 is 
      consistent with the predominantly monocytic effusion found in EPA synovia.
CI  - Copyright 2000 S. Karger AG, Basel.
FAU - Mateo, L
AU  - Mateo L
AD  - Australian Centre for International and Tropical Health and Nutrition, Queensland 
      Institute of Medical Research and the University of Queensland, Brisbane, Qld., 
      Australia.
FAU - La Linn, M
AU  - La Linn M
FAU - McColl, S R
AU  - McColl SR
FAU - Cross, S
AU  - Cross S
FAU - Gardner, J
AU  - Gardner J
FAU - Suhrbier, A
AU  - Suhrbier A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Intervirology
JT  - Intervirology
JID - 0364265
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-8)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Alphavirus Infections/virology
MH  - Animals
MH  - Arthritis, Infectious/virology
MH  - Cell Line
MH  - Cells, Cultured
MH  - Chemokine CCL2/*biosynthesis/genetics
MH  - Chemokines/biosynthesis/genetics
MH  - Cytokines/biosynthesis/genetics
MH  - Fibroblasts/*immunology/virology
MH  - Humans
MH  - Interleukin-8/*biosynthesis/genetics
MH  - Macrophages/*immunology/virology
MH  - Mice
MH  - RNA, Messenger/genetics/metabolism
MH  - Ross River virus/pathogenicity/*physiology
MH  - Synovial Membrane
MH  - Up-Regulation
EDAT- 2000/04/25 09:00
MHDA- 2000/06/24 11:00
CRDT- 2000/04/25 09:00
PHST- 2000/04/25 09:00 [pubmed]
PHST- 2000/06/24 11:00 [medline]
PHST- 2000/04/25 09:00 [entrez]
AID - 25023 [pii]
AID - 10.1159/000025023 [doi]
PST - ppublish
SO  - Intervirology. 2000;43(1):55-60. doi: 10.1159/000025023.