PMID- 10773849
OWN - NLM
STAT- MEDLINE
DCOM- 20000524
LR  - 20170214
IS  - 1352-4585 (Print)
IS  - 1352-4585 (Linking)
VI  - 6
IP  - 2
DP  - 2000 Apr
TI  - Leukotropic herpesviruses in multiple sclerosis.
PG  - 66-8
AB  - Detection frequency of human herpesvirus 6 (HHV-6) and Epstein Barr virus (EBV) 
      DNA in multiple sclerosis (MS) patients and controls was investigated. DNA of 
      peripheral blood mononuclear leukocytes (PBL) was isolated and amplified by 
      polymerase chain reaction techniques. EBV DNA was detected in all patients and 
      controls. HHV-6 DNA was detected in 7% of MS patients and in 14% of controls. 
      Results are compared with other investigations of HHV-6 DNA in PBL, serum, CSF 
      and brain of patients with MS. Results of the present study and other 
      investigations do not show an association between HHV-6 in PBL and MS. Multiple 
      Sclerosis (2000) 6, 66 - 68
FAU - Hay, K A
AU  - Hay KA
AD  - Department of Medicine (Neurology), Penn State University College of Medicine, 
      Hershey, Pennsylvania, USA.
FAU - Tenser, R B
AU  - Tenser RB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
RN  - 0 (DNA, Viral)
SB  - IM
MH  - DNA, Viral/*blood
MH  - Herpesvirus 4, Human/genetics
MH  - Herpesvirus 6, Human/*genetics
MH  - Humans
MH  - Monocytes/metabolism
MH  - Multiple Sclerosis, Chronic Progressive/*blood/*virology
MH  - Multiple Sclerosis, Relapsing-Remitting/*blood/*virology
MH  - Reference Values
EDAT- 2000/04/25 09:00
MHDA- 2000/06/08 09:00
CRDT- 2000/04/25 09:00
PHST- 2000/04/25 09:00 [pubmed]
PHST- 2000/06/08 09:00 [medline]
PHST- 2000/04/25 09:00 [entrez]
AID - 10.1177/135245850000600202 [doi]
PST - ppublish
SO  - Mult Scler. 2000 Apr;6(2):66-8. doi: 10.1177/135245850000600202.