PMID- 10773851
OWN - NLM
STAT- MEDLINE
DCOM- 20000524
LR  - 20170214
IS  - 1352-4585 (Print)
IS  - 1352-4585 (Linking)
VI  - 6
IP  - 2
DP  - 2000 Apr
TI  - TNF-alpha polymorphisms in multiple sclerosis: no association with -238 and -308 
      promoter alleles, but the microsatellite allele a11 is associated with the 
      disease in French patients.
PG  - 78-80
AB  - Tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine, is believed 
      to play an important role in multiple sclerosis (MS) pathogenesis. The objective 
      of this study was to determine whether sequence variation in the TNF-alpha gene 
      is associated with MS. Bi-allelic polymorphisms in the TNF-alpha promoter region 
      (TNF-alpha -238 and -308) and microsatellite TNF-alpha were previously reported. 
      We investigated these polymorphisms in 74 French patients with MS, compared with 
      75 controls. No significant differences regarding the TNF-alpha -238 and -308 
      polymorphisms were observed between MS patients and controls. Allele frequency 
      for the a11 allele is in very significant association (P<0.0001) with MS, due in 
      part to the association of the a11 allele with the HLA-DRB1*15 allele in 
      patients.
FAU - Lucotte, G
AU  - Lucotte G
AD  - Center of Molecular Neurogenetics, Faculty of Medicine, Rheims, France.
FAU - Bathelier, C
AU  - Bathelier C
FAU - Mercier, G
AU  - Mercier G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Alleles
MH  - Female
MH  - France
MH  - Gene Frequency
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Male
MH  - Microsatellite Repeats
MH  - Multiple Sclerosis/*genetics/immunology
MH  - *Polymorphism, Genetic
MH  - Promoter Regions, Genetic/genetics
MH  - Reference Values
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2000/04/25 09:00
MHDA- 2000/06/08 09:00
CRDT- 2000/04/25 09:00
PHST- 2000/04/25 09:00 [pubmed]
PHST- 2000/06/08 09:00 [medline]
PHST- 2000/04/25 09:00 [entrez]
AID - 10.1177/135245850000600204 [doi]
PST - ppublish
SO  - Mult Scler. 2000 Apr;6(2):78-80. doi: 10.1177/135245850000600204.