PMID- 10774456
OWN - NLM
STAT- MEDLINE
DCOM- 20000525
LR  - 20211203
IS  - 0066-4219 (Print)
IS  - 0066-4219 (Linking)
VI  - 51
DP  - 2000
TI  - New horizons in the treatment of autoimmune diseases: immunoablation and stem 
      cell transplantation.
PG  - 115-34
AB  - The prevalence of autoimmune diseases (ADs) in Western countries is estimated to 
      be from 3-7%, and the treatment of severe, relapsing/refractory cases is still 
      not satisfactory. The concept of utilizing intense immunosuppression followed by 
      allogeneic or even autologous hemolymphopoietic stem cells (HSCs) to treat AD is 
      based on encouraging results in experimental animals and from serendipitous cases 
      of patients with both ADs and malignancies who were allotransplanted for the 
      latter. However, rare unexpected relapses despite donor immune engraftment have 
      been reported following HSC transplantation for AD. Autologous transplantation is 
      a more feasible procedure with lower toxicity than allogeneic transplantation. 
      This article analyzes the experimental basis for stem cell transplantation in AD 
      and discusses the most important clinical results of both allogeneic and 
      autologous HSC transplants.
FAU - Marmont, A M
AU  - Marmont AM
AD  - Department of Hematology (DEMA), S. Martino's Hospital, Genova, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Annu Rev Med
JT  - Annual review of medicine
JID - 2985151R
SB  - IM
MH  - Animals
MH  - Arthritis, Rheumatoid/therapy
MH  - Autoimmune Diseases/*therapy
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - *Immunosuppression Therapy
MH  - Scleroderma, Systemic/therapy
MH  - Transplantation, Autologous
RF  - 111
EDAT- 2000/04/25 09:00
MHDA- 2000/06/08 09:00
CRDT- 2000/04/25 09:00
PHST- 2000/04/25 09:00 [pubmed]
PHST- 2000/06/08 09:00 [medline]
PHST- 2000/04/25 09:00 [entrez]
AID - 10.1146/annurev.med.51.1.115 [doi]
PST - ppublish
SO  - Annu Rev Med. 2000;51:115-34. doi: 10.1146/annurev.med.51.1.115.