PMID- 10777169
OWN - NLM
STAT- MEDLINE
DCOM- 20000713
LR  - 20051116
IS  - 0192-0790 (Print)
IS  - 0192-0790 (Linking)
VI  - 30
IP  - 3 Suppl
DP  - 2000 Apr
TI  - Laryngeal complications of GERD.
PG  - S31-4
AB  - Anatomic proximity of the larynx and hypopharynx make these structures 
      particularly susceptible to acid and bile exposure due to gastroesophageal reflux 
      disease (GERD). There is an increasingly expansive list of signs and symptoms 
      that can occur on the larynx and upper airway as a consequence of GERD. A high 
      index of suspicion must be maintained to property diagnose and manage the 
      laryngeal complications of GERD. Reflux of gastric contents into the 
      laryngopharynx is best demonstrated by a dual- or triple-sensor pH probe study. 
      Alternatively, an empiric trial of proton pump therapy as a diagnostic test has 
      sensitivity/specificity that is comparable to pH studies. This approach provides 
      both diagnostic and therapeutic advantage. Following improvement of symptoms, 
      reduction of the medication should be attempted, with the target of either 
      withdrawing therapy or using the lowest dose to control symptoms. Surgical 
      intervention for laryngeal complications is predictably better in patients who 
      have responded to proton pump inhibitor (PPI) therapy.
FAU - Gaynor, E B
AU  - Gaynor EB
AD  - Department of Otolaryngology, Norwalk Hospital, Connecticut, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Clin Gastroenterol
JT  - Journal of clinical gastroenterology
JID - 7910017
SB  - IM
MH  - Diagnosis, Differential
MH  - Gastroesophageal Reflux/*complications/diagnosis
MH  - Humans
MH  - Laryngeal Diseases/diagnosis/*etiology
RF  - 31
EDAT- 2000/04/25 09:00
MHDA- 2000/07/15 11:00
CRDT- 2000/04/25 09:00
PHST- 2000/04/25 09:00 [pubmed]
PHST- 2000/07/15 11:00 [medline]
PHST- 2000/04/25 09:00 [entrez]
PST - ppublish
SO  - J Clin Gastroenterol. 2000 Apr;30(3 Suppl):S31-4.