PMID- 10777780
OWN - NLM
STAT- MEDLINE
DCOM- 20000602
LR  - 20231014
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 20
IP  - 9
DP  - 2000 May 1
TI  - Brain-derived neurotrophic factor (BDNF) induces dendritic targeting of BDNF and 
      tyrosine kinase B mRNAs in hippocampal neurons through a phosphatidylinositol-3 
      kinase-dependent pathway.
PG  - 3165-74
AB  - This study aims to understand the mechanisms of dendritic targeting of 
      brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) mRNAs. We 
      show that brief depolarizations are sufficient to induce accumulation of BDNF and 
      TrkB mRNAs in dendrites of hippocampal neurons. Endogenous BDNF, secreted during 
      the KCl stimulation, contributes significantly to the dendritic accumulation of 
      BDNF-TrkB mRNAs. In the absence of depolarization, 1 min pulses of exogenous BDNF 
      are sufficient to induce dendritic accumulation of BDNF-TrkB mRNAs. After binding 
      to TrkB, BDNF exerts this action by activating a PI-3 kinase-dependent pathway. 
      The accumulation of dendritic mRNA by BDNF is not mediated by BDNF-induced 
      neurotransmitter release. Because most hippocampal neurons coexpress BDNF and 
      TrkB receptors, these results show that the subcellular distribution of BDNF-TrkB 
      mRNAs is under the control of an autocrine-paracrine BDNF-TrkB-dependent loop.
FAU - Righi, M
AU  - Righi M
AD  - International School for Advanced Studies (ISAS/SISSA), Neuroscience Program, 
      34014 Trieste, Italy.
FAU - Tongiorgi, E
AU  - Tongiorgi E
FAU - Cattaneo, A
AU  - Cattaneo A
LA  - eng
GR  - E.0954/TI_/Telethon/Italy
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (RNA, Messenger)
RN  - 660YQ98I10 (Potassium Chloride)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/drug effects/pharmacology/*physiology
MH  - Cells, Cultured
MH  - Dendrites/drug effects/*metabolism
MH  - Enzyme Inhibitors/pharmacology
MH  - Hippocampus/drug effects/*metabolism
MH  - Neurons/drug effects/metabolism
MH  - Phosphatidylinositol 3-Kinases/drug effects/*metabolism
MH  - Potassium Chloride/pharmacology
MH  - RNA, Messenger/drug effects/metabolism
MH  - Rats
MH  - Receptor, trkB/drug effects/*metabolism
MH  - Signal Transduction/drug effects/physiology
PMC - PMC6773127
EDAT- 2000/04/25 00:00
MHDA- 2000/06/10 00:00
PMCR- 2000/11/01
CRDT- 2000/04/25 00:00
PHST- 2000/04/25 00:00 [pubmed]
PHST- 2000/06/10 00:00 [medline]
PHST- 2000/04/25 00:00 [entrez]
PHST- 2000/11/01 00:00 [pmc-release]
AID - 4131 [pii]
AID - 10.1523/JNEUROSCI.20-09-03165.2000 [doi]
PST - ppublish
SO  - J Neurosci. 2000 May 1;20(9):3165-74. doi: 10.1523/JNEUROSCI.20-09-03165.2000.