PMID- 10778951
OWN - NLM
STAT- MEDLINE
DCOM- 20000803
LR  - 20220311
IS  - 1078-0432 (Print)
IS  - 1078-0432 (Linking)
VI  - 6
IP  - 4
DP  - 2000 Apr
TI  - Mouse mammary tumor virus-like ENV gene sequences in human breast tumors and in a 
      lymphoma of a breast cancer patient.
PG  - 1273-8
AB  - DNA sequences with very high similarity (95-98%) to the mouse mammary tumor virus 
      (MMTV) ENV gene have been amplified by PCR in 38.5% of human breast tumors and in 
      <2% of normal breast tissue (Wang et al., Cancer Res., 55: 5173-5179, 1995). 
      Intrigued by these findings, which suggested an exogenous viral etiology for a 
      certain percentage of human breast tumors, we have screened a panel of human 
      breast tumors and normal breast tissue for the presence of MMTV-like DNA 
      sequences. Using similar PCR procedures and stringent hybridization techniques, 
      we have detected the presence of MMTV-like ENV gene sequences in 37% of the human 
      breast tumors that we have analyzed. DNA sequencing has shown these sequences to 
      be 99% homologous to the BR6 strain of MMTV and 100% homologous to the GR and C3H 
      strains of MMTV. We have not detected these MMTV-like sequences in normal breast 
      tissue. However, we have detected these sequences by PCR and stringent 
      hybridization in a T-cell lymphoma of a breast cancer patient who was 
      simultaneously diagnosed with both diseases. Our results support the possibility 
      of an exogenous retroviral etiology for a certain percentage of human breast 
      tumors. Our results also suggest that a similar exogenous retroviral etiology may 
      exist for certain human T-cell lymphomas. In many inbred strains of mice, both 
      breast cancer and T-cell lymphoma are caused by MMTV, hence, in a certain 
      percentage of humans, one or both of these diseases may be caused by an MMTV-like 
      retroviral entity.
FAU - Etkind, P
AU  - Etkind P
AD  - Our Lady of Mercy Medical Center-Comprehensive Cancer Center, New York Medical 
      College, Bronx 10466-4002, USA.
FAU - Du, J
AU  - Du J
FAU - Khan, A
AU  - Khan A
FAU - Pillitteri, J
AU  - Pillitteri J
FAU - Wiernik, P H
AU  - Wiernik PH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Cancer Res
JT  - Clinical cancer research : an official journal of the American Association for 
      Cancer Research
JID - 9502500
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Animals
MH  - Base Sequence
MH  - Breast/pathology/virology
MH  - Breast Neoplasms/*virology
MH  - DNA, Viral/chemistry/genetics
MH  - Female
MH  - Genes, env/*genetics
MH  - Humans
MH  - Lymphoma, T-Cell/*virology
MH  - Mammary Tumor Virus, Mouse/*genetics
MH  - Mice
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Sequence Alignment
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Nucleic Acid
MH  - Tumor Cells, Cultured
EDAT- 2000/04/25 09:00
MHDA- 2000/08/06 11:00
CRDT- 2000/04/25 09:00
PHST- 2000/04/25 09:00 [pubmed]
PHST- 2000/08/06 11:00 [medline]
PHST- 2000/04/25 09:00 [entrez]
PST - ppublish
SO  - Clin Cancer Res. 2000 Apr;6(4):1273-8.