PMID- 10779642
OWN - NLM
STAT- MEDLINE
DCOM- 20000613
LR  - 20190720
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 153
IP  - 1-2
DP  - 2000 May 29
TI  - Possible role of hepatocyte growth factor/scatter factor and activin A produced 
      by the target organ in liver metastasis.
PG  - 137-43
AB  - The molecular mechanism of organ-specific metastasis to the liver remains largely 
      unknown. However, it is conceivable that paracrine growth factors produced by a 
      target organ induce migration and proliferation of malignant cells to that organ, 
      and this is the cause of organ-specific metastasis. In this study, we 
      investigated the effect of hepatocyte growth factor/scatter factor (HGF/SF) and 
      activin A, which are known to be produced by the liver, on the motility and 
      growth of liver-metastatic cell line FBJ-LL. HGF/SF and activin A induced 
      motility synergistically, but they did not affect the proliferation of FBJ-LL 
      cells. Expression of the HGF/SF receptor, the c-met gene, and the 
      activin-receptor type IA, type IB, and type IIA genes in FBJ-LL cells was 
      detected by reverse transcription polymerase chain reaction. These findings 
      suggest that both HGF/SF and activin A promote organ-specific metastasis to the 
      liver by induction of migration through their specific receptors on 
      liver-metastatic cells.
FAU - Hyuga, S
AU  - Hyuga S
AD  - Division of Biological Chemistry and Biologicals, National Institute of Health 
      Sciences, 1-18-1, Kamiyoga, Setagayaku, Tokyo, Japan. hyuga@nihs.go.jp
FAU - Kawasaki, N
AU  - Kawasaki N
FAU - Hashimoto, O
AU  - Hashimoto O
FAU - Hyuga, M
AU  - Hyuga M
FAU - Ohta, M
AU  - Ohta M
FAU - Yamagata, S
AU  - Yamagata S
FAU - Yamagata, T
AU  - Yamagata T
FAU - Hayakawa, T
AU  - Hayakawa T
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Receptors, Growth Factor)
RN  - 104625-48-1 (Activins)
RN  - 57285-09-3 (Inhibins)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
RN  - EC 2.7.11.30 (Activin Receptors, Type I)
SB  - IM
MH  - Activin Receptors, Type I
MH  - Activins
MH  - Animals
MH  - Cell Division/physiology
MH  - Cell Movement/physiology
MH  - Hepatocyte Growth Factor/*physiology
MH  - Inhibins/*physiology
MH  - Liver Neoplasms/pathology/*secondary
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Proto-Oncogene Proteins c-met/analysis
MH  - Receptors, Growth Factor/analysis
MH  - Tumor Cells, Cultured
EDAT- 2000/04/26 09:00
MHDA- 2000/06/17 09:00
CRDT- 2000/04/26 09:00
PHST- 2000/04/26 09:00 [pubmed]
PHST- 2000/06/17 09:00 [medline]
PHST- 2000/04/26 09:00 [entrez]
AID - S0304383500003608 [pii]
AID - 10.1016/s0304-3835(00)00360-8 [doi]
PST - ppublish
SO  - Cancer Lett. 2000 May 29;153(1-2):137-43. doi: 10.1016/s0304-3835(00)00360-8.