PMID- 10780286
OWN - NLM
STAT- MEDLINE
DCOM- 20000518
LR  - 20191103
IS  - 0955-8810 (Print)
IS  - 0955-8810 (Linking)
VI  - 10
IP  - 8
DP  - 1999 Dec
TI  - Assessment of D3 versus D2 receptor modulation of the discriminative stimulus 
      effects of (+)-7-OH-DPAT in rats.
PG  - 717-22
AB  - Although there are presently no highly selective agonists for the D3 dopamine 
      receptor, a number of compounds reported to bind with moderate selectivity to D3 
      receptors are currently employed to investigate the importance of D3 receptors in 
      the behavioral effects of psychostimulant drugs. For example, 
      7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT) has been used extensively 
      to investigate the role of D3 receptors in the reinforcing and discriminative 
      stimulus properties of cocaine and d-amphetamine. However, recent investigations 
      with a relatively selective D3 antagonist, PNU-99194A, have led us to question 
      the importance of D3 receptors in the discriminative stimulus effects of 
      7-OH-DPAT. In the present study, 16 male Sprague-Dawley rats were trained to 
      discriminate (+)-7-OH-DPAT (0.03 mg/kg, subcutaneously (s.c.)) from saline in a 
      two-choice operant procedure using a fixed-ratio 20 schedule of water 
      reinforcement. Consistent with previous findings, PNU-99194A appeared to 
      attenuate only partially (+)-7-OH-DPAT discrimination at a dose that disrupted 
      responding in most subjects. Moreover, a highly selective D2 agonist, PNU-91356A, 
      substituted completely and in a dose-dependent manner for (+)-7-OH-DPAT, while 
      d-amphetamine produced only partial substitution for the training drug. These 
      data indicate that D2 receptor actions appear to be more important than D3 
      receptor actions in exerting the discriminative stimulus effects of 
      (+)-7-OH-DPAT. Continued efforts to determine the relative importance of D2 vs D3 
      receptor actions in the modulation of the discriminative stimulus effects of 
      (+)-7-OH-DPAT are discussed.
FAU - Baker, L E
AU  - Baker LE
AD  - Department of Psychology, Western Michigan University, Kalamazoo 49008, USA. 
      Lisa.Baker@wmich.edu
FAU - Hood, C A
AU  - Hood CA
FAU - Heidema, A M
AU  - Heidema AM
LA  - eng
GR  - 1-RO3-DA11291/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Behav Pharmacol
JT  - Behavioural pharmacology
JID - 9013016
RN  - 0 (Dopamine Agents)
RN  - 0 (Dopamine Agonists)
RN  - 0 (Dopamine Antagonists)
RN  - 0 (Drd3 protein, rat)
RN  - 0 (Indans)
RN  - 0 (Receptors, Dopamine D2)
RN  - 0 (Receptors, Dopamine D3)
RN  - 0 (Tetrahydronaphthalenes)
RN  - 153570-58-2 ((5,6-dimethoxyindan-2-yl)dipropylamine)
RN  - RR7D75YDF4 (7-hydroxy-2-N,N-dipropylaminotetralin)
RN  - TZ47U051FI (Dextroamphetamine)
SB  - IM
MH  - Animals
MH  - Cues
MH  - Dextroamphetamine/pharmacology
MH  - Discrimination Learning/*drug effects
MH  - Dopamine Agents/pharmacology
MH  - Dopamine Agonists/*pharmacology
MH  - Dopamine Antagonists/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Generalization, Stimulus/drug effects
MH  - Indans/pharmacology
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Dopamine D2/*drug effects
MH  - Receptors, Dopamine D3
MH  - Stereoisomerism
MH  - Tetrahydronaphthalenes/antagonists & inhibitors/*pharmacology
EDAT- 2000/04/26 09:00
MHDA- 2000/05/20 09:00
CRDT- 2000/04/26 09:00
PHST- 2000/04/26 09:00 [pubmed]
PHST- 2000/05/20 09:00 [medline]
PHST- 2000/04/26 09:00 [entrez]
AID - 10.1097/00008877-199912000-00002 [doi]
PST - ppublish
SO  - Behav Pharmacol. 1999 Dec;10(8):717-22. doi: 10.1097/00008877-199912000-00002.