PMID- 10780312
OWN - NLM
STAT- MEDLINE
DCOM- 20000731
LR  - 20061115
IS  - 0340-6245 (Print)
IS  - 0340-6245 (Linking)
VI  - 83
IP  - 4
DP  - 2000 Apr
TI  - Recurrent venous thrombosis and markers of inflammation.
PG  - 536-9
AB  - Inflammatory processes may play a key role in venous thrombosis, by inducing a 
      procoagulant state through the action of cytokines and chemokines on monocytes 
      and endothelial cells. Plasma concentrations of three inflammatory mediators, 
      interleukin 6 (IL-6), interleukin 8 (IL-8) and monocyte chemotactic protein 1 
      (MCP-1), that mediate the cross-talk between inflammation and coagulation, were 
      measured in 182 subjects with recurrent venous thrombosis and 350 healthy 
      subjects recruited through a general practice. Elevated levels of IL-6 (>90th 
      percentile of the control group) were detected in 25.8% of the patients with 
      venous thrombosis in comparison with 10% (by definition) of the controls [odds 
      ratio 2.4 (95%CI 1.5-3.8)]. In 21.5% of the patients elevated plasma levels of 
      IL-8 (>90th percentile) were determined [odds ratio 2.0 (95%CI 1.2-3.5)]. 
      Elevated levels of MCP-1 (>90th percentile) were detected in 24.1% of the 
      patients [odds ratio 1.9 (95%CI 1.2-3.2)]. This is the first large clinical study 
      showing that an increase in inflammatory mediators is associated with venous 
      thrombosis. Future prospective studies are necessary to clarify the causal nature 
      of the inflammatory process with respect to venous thrombosis.
FAU - van Aken, B E
AU  - van Aken BE
AD  - Laboratory for Experimental Internal Medicine, University Hospital Nijmegen, The 
      Netherlands.
FAU - den Heijer, M
AU  - den Heijer M
FAU - Bos, G M
AU  - Bos GM
FAU - van Deventer, S J
AU  - van Deventer SJ
FAU - Reitsma, P H
AU  - Reitsma PH
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Thromb Haemost
JT  - Thrombosis and haemostasis
JID - 7608063
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Humans
MH  - Inflammation
MH  - Interleukin-6/*blood
MH  - Interleukin-8/*blood
MH  - Male
MH  - Middle Aged
MH  - Netherlands/epidemiology
MH  - Odds Ratio
MH  - Recurrence
MH  - Thrombophlebitis/blood/epidemiology
MH  - Venous Thrombosis/*blood/epidemiology
EDAT- 2000/04/26 09:00
MHDA- 2000/08/06 11:00
CRDT- 2000/04/26 09:00
PHST- 2000/04/26 09:00 [pubmed]
PHST- 2000/08/06 11:00 [medline]
PHST- 2000/04/26 09:00 [entrez]
AID - 00040536 [pii]
PST - ppublish
SO  - Thromb Haemost. 2000 Apr;83(4):536-9.