PMID- 10780803
OWN - NLM
STAT- MEDLINE
DCOM- 20000524
LR  - 20191103
IS  - 0955-8810 (Print)
IS  - 0955-8810 (Linking)
VI  - 10
IP  - 4
DP  - 1999 Jul
TI  - Effects of lithium dose (UCS) on the acquisition and extinction of a 
      discriminated morphine aversion: tests with morphine and delta9-THC.
PG  - 349-58
AB  - The effects of varying the lithium dose (unconditioned stimulus [UCS]; LiCl range 
      30-180 mg/kg) on the acquisition and extinction of stimulus control by 5.6 mg/kg 
      of morphine in a discriminated taste aversion (DTA) procedure were examined in 
      rats. In addition, pharmacological specificity was examined by substituting 
      (-)-delta-9-tetrahydrocannabinol (delta9-THC) for morphine during a test phase 
      intervening between acquisition and extinction. DTA acquisition was more rapid at 
      higher LiCl doses. The lowest dose of LiCl, 30 mg/kg, did not robustly maintain a 
      DTA. Two groups treated with 60 mg/kg LiCl, differing only in the type of 
      drinking nozzle used (ball-bearing vs standard non-ball-bearing), behaved 
      similarly. Suppression of drinking was related to the morphine dose, in an 
      orderly manner (dose range 0.3-10 mg/kg), in rats for which morphine was followed 
      by LiCl. No significant decline in drinking occurred for rats for which morphine 
      was followed by saline, except perhaps at the 10 mg/kg test dose of morphine. The 
      control of drinking was pharmacologically specific; both experimental and control 
      animals were equally affected in tests with delta9-THC (0.3-10 mg/kg). Low doses 
      of delta9-THC increased water consumption; this did not occur with morphine. 
      During extinction the reinstitution of drinking was similar across groups that 
      had been effectively conditioned, i.e. there was no apparent effect of lithium 
      dose on extinction. After extinction, a much attenuated reaction occurred to 
      morphine in tests with 3 and 10 mg/kg. These doses of morphine had significantly 
      suppressed drinking before the extinction phase. Collectively, these data add to 
      the formal similarities between sensory and drug discriminative stimuli.
FAU - Jarbe, T U
AU  - Jarbe TU
AD  - Department of Psychiatry, MCP Hahnemann University, Philadelphia, Pennsylvania, 
      USA.
FAU - Lamb, R J
AU  - Lamb RJ
LA  - eng
GR  - DA 09064/DA/NIDA NIH HHS/United States
GR  - KO2-DA 00253/DA/NIDA NIH HHS/United States
GR  - R01-DA 08395/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Behav Pharmacol
JT  - Behavioural pharmacology
JID - 9013016
RN  - 0 (Hallucinogens)
RN  - 0 (Narcotics)
RN  - 76I7G6D29C (Morphine)
RN  - 7J8897W37S (Dronabinol)
RN  - G4962QA067 (Lithium Chloride)
SB  - IM
MH  - Animals
MH  - Conditioning, Operant/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Dronabinol/*pharmacology
MH  - Extinction, Psychological/*drug effects
MH  - Hallucinogens/*pharmacology
MH  - Injections, Intraperitoneal
MH  - Lithium Chloride/administration & dosage/*pharmacology
MH  - Male
MH  - Morphine/*pharmacology
MH  - Narcotics/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2000/04/26 09:00
MHDA- 2000/06/08 09:00
CRDT- 2000/04/26 09:00
PHST- 2000/04/26 09:00 [pubmed]
PHST- 2000/06/08 09:00 [medline]
PHST- 2000/04/26 09:00 [entrez]
AID - 10.1097/00008877-199907000-00002 [doi]
PST - ppublish
SO  - Behav Pharmacol. 1999 Jul;10(4):349-58. doi: 10.1097/00008877-199907000-00002.