PMID- 10780848
OWN - NLM
STAT- MEDLINE
DCOM- 20000505
LR  - 20170214
IS  - 0023-6772 (Print)
IS  - 0023-6772 (Linking)
VI  - 33
IP  - 3
DP  - 1999 Jul
TI  - Haematology and serum chemistry parameters of the pregnant rat.
PG  - 275-87
AB  - This study describes the baseline haematology and serum chemistry values found in 
      non-pregnant, pregnant (gestational days [GD] 2-21) and lactating (postnatal days 
      1-9) Sprague Dawley rats (n = 3-10/day) from the NCTR breeding colony of Crl:COBS 
      CD(SD)BR strain. Maternal body weights on GD0 ranged from 250 to 300 g. Multiple 
      analytes were measured in both whole blood and serum of dams. Amniotic fluid, 
      fetal serum, and postnatal pup serum analyte values were also acquired. Maternal 
      blood was collected from the heart under subterminal carbon dioxide (CO2) 
      anaesthesia. Most pregnant dam blood values were not appreciably different from 
      values for non-pregnant dams until near term; near-term values for some analytes 
      (red blood cells, haemoglobin, haematocrit, mean corpuscular haemoglobin 
      concentration, alkaline phosphatase, albumin, total protein, glucose, total 
      bilirubin, sodium, and chloride) decreased but returned to near-normal values 
      soon after delivery. The most dramatic change was a three-fold elevation of serum 
      triglyceride levels near term with a subsequent decrease at birth. Most serum 
      chemistry analytes measured in progeny increased after birth except for alkaline 
      phosphatase, calcium and potassium levels which decreased.
FAU - LaBorde, J B
AU  - LaBorde JB
AD  - Division of Genetic and Reproductive Toxicology, National Center for 
      Toxicological Research, Food & Drug Administration, Jefferson, AR 72079-9502, 
      USA.
FAU - Wall, K S
AU  - Wall KS
FAU - Bolon, B
AU  - Bolon B
FAU - Kumpe, T S
AU  - Kumpe TS
FAU - Patton, R
AU  - Patton R
FAU - Zheng, Q
AU  - Zheng Q
FAU - Kodell, R
AU  - Kodell R
FAU - Young, J F
AU  - Young JF
LA  - eng
PT  - Journal Article
PL  - England
TA  - Lab Anim
JT  - Laboratory animals
JID - 0112725
RN  - 0 (Blood Proteins)
RN  - 0 (Electrolytes)
RN  - 0 (Hemoglobins)
RN  - 0 (Triglycerides)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Amniotic Fluid/chemistry
MH  - Animals
MH  - Animals, Newborn/blood
MH  - *Blood Chemical Analysis
MH  - Blood Proteins/analysis
MH  - Calcium/blood
MH  - Electrolytes/blood
MH  - Erythrocyte Count
MH  - Erythrocyte Indices
MH  - Female
MH  - Fetal Blood/chemistry
MH  - Gestational Age
MH  - Hematocrit
MH  - *Hematologic Tests
MH  - Hemoglobins/analysis
MH  - Lactation
MH  - Pregnancy
MH  - Pregnancy, Animal/*blood
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Triglycerides/blood
EDAT- 2000/04/26 09:00
MHDA- 2000/05/16 09:00
CRDT- 2000/04/26 09:00
PHST- 2000/04/26 09:00 [pubmed]
PHST- 2000/05/16 09:00 [medline]
PHST- 2000/04/26 09:00 [entrez]
AID - 10.1258/002367799780578156 [doi]
PST - ppublish
SO  - Lab Anim. 1999 Jul;33(3):275-87. doi: 10.1258/002367799780578156.