PMID- 10780855
OWN - NLM
STAT- MEDLINE
DCOM- 20000725
LR  - 20041117
IS  - 0884-0431 (Print)
IS  - 0884-0431 (Linking)
VI  - 15
IP  - 4
DP  - 2000 Apr
TI  - Transforming growth factor-beta1 gene polymorphism, bone turnover, and bone mass 
      in Italian postmenopausal women.
PG  - 634-9
AB  - Transforming growth factor beta1 (TGF-beta1) is abundant in bone and is an 
      important regulator of the osteoclastic-osteoblastic interaction (coupling). The 
      sequence variation, 713-8delC in the TGF-beta1 gene has previously been found to 
      be associated with very low bone mass in osteoporotic women and with increased 
      bone turnover in both osteoporotic and normal women. The possible association of 
      this polymorphism with bone mass and bone turnover has now been investigated in 
      256 postmenopausal Italian women. A significant association of TGF-beta1 with 
      bone mass was detected in the populations. Subjects carrying the sequence 
      variation 713-8delC (Tt) genotype showed a significantly lower bone mineral 
      density (BMD) at the hip than those without sequence variation in the genotype 
      (TT). Individuals carrying the tt genotype have a more severe osteoporosis 
      (P=0.0001 vs. TT and Tt genotypes). The frequency of the fragility fractures was 
      significantly lower in individuals with TT genotype than in those with the Tt and 
      tt genotypes (X2=21.9; P=0.006). Furthermore a significant association was found 
      between 713-8delC and bone turnover. The results suggest a strong evidence for an 
      association among the 713-8delC allele of the TGF-beta1 gene and the femoral BMD, 
      the prevalence of osteoporotic fractures, and finally a high bone turnover in a 
      sample of Italian postmenopausal women.
FAU - Bertoldo, F
AU  - Bertoldo F
AD  - Dipartimento di Scienze Biomediche e Chirurgiche, Universita' di Verona, Italy.
FAU - D'Agruma, L
AU  - D'Agruma L
FAU - Furlan, F
AU  - Furlan F
FAU - Colapietro, F
AU  - Colapietro F
FAU - Lorenzi, M T
AU  - Lorenzi MT
FAU - Maiorano, N
AU  - Maiorano N
FAU - Iolascon, A
AU  - Iolascon A
FAU - Zelante, L
AU  - Zelante L
FAU - Locascio, V
AU  - Locascio V
FAU - Gasparini, P
AU  - Gasparini P
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Bone Miner Res
JT  - Journal of bone and mineral research : the official journal of the American 
      Society for Bone and Mineral Research
JID - 8610640
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Aged
MH  - Bone Density
MH  - Female
MH  - Humans
MH  - Italy
MH  - Middle Aged
MH  - Osteoporosis, Postmenopausal/*genetics/physiopathology
MH  - *Polymorphism, Genetic
MH  - Postmenopause/*physiology
MH  - Transforming Growth Factor beta/*genetics
EDAT- 2000/04/26 09:00
MHDA- 2000/08/01 11:00
CRDT- 2000/04/26 09:00
PHST- 2000/04/26 09:00 [pubmed]
PHST- 2000/08/01 11:00 [medline]
PHST- 2000/04/26 09:00 [entrez]
AID - 10.1359/jbmr.2000.15.4.634 [doi]
PST - ppublish
SO  - J Bone Miner Res. 2000 Apr;15(4):634-9. doi: 10.1359/jbmr.2000.15.4.634.