PMID- 10781920
OWN - NLM
STAT- MEDLINE
DCOM- 20000621
LR  - 20210112
IS  - 0304-3959 (Print)
IS  - 0304-3959 (Linking)
VI  - 85
IP  - 3
DP  - 2000 Apr
TI  - Synergistic effect of cholecystokinin octapeptide and angiotensin II in reversal 
      of morphine induced analgesia in rats.
PG  - 465-469
LID - 10.1016/S0304-3959(99)00294-8 [doi]
AB  - The aim of this paper is to study the synergistic anti-analgesic effect of 
      angiotensin II (Ang II) plus cholecystokinin octapeptide (CCK-8). Our previous 
      studies have shown that both CCK-8 and Ang II are potent anti-opioid substances. 
      Intracerebroventricular (i.c.v.) injection of CCK-8 or Ang II dose-dependently 
      antagonizes morphine-induced analgesia (MIA). In the present study, we observed 
      the combined effect of CCK-8 and Ang II in antagonizing MIA. CCK-8 and Ang II 
      were injected intracerebroventricularly to rats in various proportions and doses. 
      The results were analyzed with isobolographic analysis. Combined injection of 
      CCK-8 and Ang II in a ratio of 1 ng: 2.5 microg or 1 ng: 5 microg produced 
      significantly greater effect in antagonizing MIA. The ED(50) of the two ratios 
      are only 18.5% and 27.5%, respectively, of the theoretical dose of simple 
      addition. We conclude that CCK-8 and Ang II used in such dose ratios may 
      antagonize MIA synergistically.
FAU - Han, Nian-Lin
AU  - Han NL
AD  - Neuroscience Research Institute, Beijing Medical University, Beijing 100083, PR 
      China Department of Physiology, Yian-Bei Nursing School, Datong, Shanxi, PR 
      China.
FAU - Luo, Fei
AU  - Luo F
FAU - Bian, Zhu-Ping
AU  - Bian ZP
FAU - Han, Ji-Sheng
AU  - Han JS
LA  - eng
GR  - DA03983/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pain
JT  - Pain
JID - 7508686
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Vasoconstrictor Agents)
RN  - 11128-99-7 (Angiotensin II)
RN  - 76I7G6D29C (Morphine)
RN  - M03GIQ7Z6P (Sincalide)
SB  - IM
MH  - Analgesics, Opioid/*antagonists & inhibitors
MH  - Angiotensin II/administration & dosage/*pharmacology
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Drug Synergism
MH  - Female
MH  - Injections, Intraventricular
MH  - Male
MH  - Morphine/*antagonists & inhibitors
MH  - Pain Measurement/drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Sincalide/administration & dosage/*pharmacology
MH  - Vasoconstrictor Agents/administration & dosage/*pharmacology
EDAT- 2000/04/27 09:00
MHDA- 2000/06/24 11:00
CRDT- 2000/04/27 09:00
PHST- 2000/04/27 09:00 [pubmed]
PHST- 2000/06/24 11:00 [medline]
PHST- 2000/04/27 09:00 [entrez]
AID - 00006396-200004010-00016 [pii]
AID - 10.1016/S0304-3959(99)00294-8 [doi]
PST - ppublish
SO  - Pain. 2000 Apr;85(3):465-469. doi: 10.1016/S0304-3959(99)00294-8.