PMID- 10781994
OWN - NLM
STAT- MEDLINE
DCOM- 20000714
LR  - 20171101
IS  - 1015-3837 (Print)
IS  - 1015-3837 (Linking)
VI  - 15
IP  - 3
DP  - 2000 May-Jun
TI  - Continuous monitoring of fetal pH, pO(2) and pCO(2) using a fiberoptic 
      multiparameter sensor in animal models reproducing in utero conditions.
PG  - 127-31
AB  - OBJECTIVES: To evaluate the feasibility and accuracy of continuous fetal 
      monitoring with a multiparameter intravascular sensor (MPIS) in animal models 
      mimicking the fetal metabolic status. METHODS: First, the accuracy of the MPIS in 
      hypoxic conditions was tested in adult rabbits (n = 6). The carotid artery (n = 
      4) or vein (n = 2) was catheterized with a 20-gauge cannula, housing a 500-microm 
      Neotrend((R)) fiberoptic sensor for pCO(2), pO(2), pH and temperature. Fiberoptic 
      readings were compared with arterial blood-gas (ABG) analyses. Secondly, the 
      feasibility of continuous fetal fiberoptic sensing was tested during experimental 
      fetoscopic surgery in lambs (n = 4). An identical sensor was introduced in a 
      chorionic artery and readings were compared to ABG analyses of fetal blood 
      samples. RESULTS: The overall bias and precision in the first experiment (147 
      measurement pairs) were -4.2 and 10.9 mm Hg for pO(2), +1.6 and 8.2 mm Hg for 
      pCO(2) and -0.015 and 0.031 for pH, respectively. In the sheep experiments, 
      continuous readings for all parameters were only available during 50% of the 
      operation time, mainly due to disturbances induced by movement, contact with 
      vessel wall and interference by endoscopic light. 20 sample pairs were obtained 
      resulting in an overall bias and precision of -3.9 and 4.3 mm Hg for pO(2), -0.74 
      and 3.68 mm Hg for pCO(2) and -0.0032 and 0. 02 for pH. CONCLUSIONS: Fiberoptic 
      microsensors are potentially useful for monitoring acid-base status in the low 
      pO(2) range present in fetal life.
CI  - Copyright 2000 S. Karger AG, Basel
FAU - Devlieger, R
AU  - Devlieger R
AD  - Center for Surgical Technologies, Faculty of Medicine, Katholieke Universiteit 
      Leuven, Belgium.
FAU - Gratacos, E
AU  - Gratacos E
FAU - Wu, J
AU  - Wu J
FAU - Yesildaglar, N
AU  - Yesildaglar N
FAU - Ghysel, C
AU  - Ghysel C
FAU - Barki, G
AU  - Barki G
FAU - Deprest, J
AU  - Deprest J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Fetal Diagn Ther
JT  - Fetal diagnosis and therapy
JID - 9107463
RN  - 142M471B3J (Carbon Dioxide)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Carbon Dioxide/*blood
MH  - Fetal Monitoring/*methods
MH  - Fetoscopy
MH  - *Fiber Optic Technology
MH  - Hydrogen-Ion Concentration
MH  - Hypoxia/blood
MH  - Oxygen/*blood
MH  - Rabbits
MH  - Sensitivity and Specificity
MH  - Sheep/embryology
EDAT- 2000/04/27 09:00
MHDA- 2000/07/25 11:00
CRDT- 2000/04/27 09:00
PHST- 2000/04/27 09:00 [pubmed]
PHST- 2000/07/25 11:00 [medline]
PHST- 2000/04/27 09:00 [entrez]
AID - 20990 [pii]
AID - 10.1159/000020990 [doi]
PST - ppublish
SO  - Fetal Diagn Ther. 2000 May-Jun;15(3):127-31. doi: 10.1159/000020990.