PMID- 10782811
OWN - NLM
STAT- MEDLINE
DCOM- 20000621
LR  - 20191210
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 27
IP  - 4
DP  - 2000 Apr
TI  - Matrix metalloproteinase-3 serum levels are correlated with disease activity and 
      predict clinical response in rheumatoid arthritis.
PG  - 888-93
AB  - OBJECTIVE: To demonstrate that serum matrix metalloproteinase-3 (MMP-3) is a 
      variable associated with disease activity and with the response to treatment in 
      rheumatoid arthritis (RA). METHODS: Serum MMP-3 levels were measured and compared 
      to biological and clinical disease activity variables in 20 patients with active 
      RA assessed serially during a one year prospective open label trial with 
      methotrexate or tenidap. RESULTS: MMP-3 levels were significantly correlated with 
      C-reactive protein (CRP) and interleukin 6 serum levels as well as with the 
      disease activity score (DAS), not only at start in untreated patients but also 
      during the 12 month followup period in both treated groups. Early changes (after 
      0.5, 1, 2, or 3 months) in MMP-3 levels were significantly associated with change 
      in DAS observed 4 to 6 months later. CONCLUSION: In addition to CRP, a systemic 
      marker of inflammation, serum MMP-3 may serve as a consistent synovial derived 
      marker of RA disease activity, early changes of which predict disease outcome.
FAU - Ribbens, C
AU  - Ribbens C
AD  - Department and Laboratory of Rheumatology, University of Liege, Belgium. 
      Clio.Ribbens@ulg.ac.be
FAU - Andre, B
AU  - Andre B
FAU - Jaspar, J M
AU  - Jaspar JM
FAU - Kaye, O
AU  - Kaye O
FAU - Kaiser, M J
AU  - Kaiser MJ
FAU - De Groote, D
AU  - De Groote D
FAU - Malaise, M G
AU  - Malaise MG
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Indoles)
RN  - 0 (Interleukin-6)
RN  - 0 (Oxindoles)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 9K7CJ74ONH (tenidap)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - YL5FZ2Y5U1 (Methotrexate)
SB  - IM
MH  - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage
MH  - Antirheumatic Agents/administration & dosage
MH  - Arthritis, Rheumatoid/diagnosis/drug therapy/*enzymology
MH  - Blood Sedimentation
MH  - C-Reactive Protein/metabolism
MH  - Female
MH  - Humans
MH  - Indoles/administration & dosage
MH  - Interleukin-6/blood
MH  - Linear Models
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood
MH  - Methotrexate/administration & dosage
MH  - Middle Aged
MH  - Oxindoles
MH  - Predictive Value of Tests
MH  - Severity of Illness Index
MH  - Treatment Outcome
EDAT- 2000/04/27 09:00
MHDA- 2000/06/24 11:00
CRDT- 2000/04/27 09:00
PHST- 2000/04/27 09:00 [pubmed]
PHST- 2000/06/24 11:00 [medline]
PHST- 2000/04/27 09:00 [entrez]
PST - ppublish
SO  - J Rheumatol. 2000 Apr;27(4):888-93.