PMID- 10782961
OWN - NLM
STAT- MEDLINE
DCOM- 20000609
LR  - 20131121
IS  - 0022-1198 (Print)
IS  - 0022-1198 (Linking)
VI  - 45
IP  - 2
DP  - 2000 Mar
TI  - Hair analysis: self-reported use of "speed" and "ecstasy" compared with 
      laboratory findings.
PG  - 400-6
AB  - Drug use histories were collected from 100 subjects recruited from the "dance 
      scene" in and around Glasgow, Scotland. In addition, each subject donated a hair 
      sample which was analyzed by gas chromatography/mass spectrometry (GC/MS) for 
      amphetamine (AP), methamphetamine (MA), 3,4-methylenedioxyamphetamine (MDA), 
      3,4-methylenedioxymethamphetamine (MD MA) and 3,4-methylenedioxyethylamphetamine 
      (MDEA). The hair samples were analyzed in two 6 cm segments or in full, ranging 
      from 1.5 to 12 cm depending on the length of the hair. Approximately 10 mg of 
      hair was ground to a fine powder before treatment with beta-glucuronidase/aryl 
      sulfatase. A solid-phase extraction procedure was carried out followed by 
      derivatization with pentafluoropropionic anhydride (PFPA). All extracts were 
      analyzed by gas chromatography/mass spectrometry (GC/MS). Of the 139 segments 
      analyzed, 77 (52.5%) were positive for at least one of the five amphetamines. The 
      drug concentrations found in the hair were compared with the self-reported drug 
      histories. A concordance of greater than 50% was found between the self-report 
      data and levels detected in hair. However, no correlation was found between the 
      reported number of "ecstasy" tablets consumed and the drug levels detected in 
      hair. An increase in the average drug levels measured was observed from low to 
      high use (number of "ecstasy" tablets/month). A large number of false negatives 
      and a low number of false positives were observed.
FAU - Cooper, G A
AU  - Cooper GA
AD  - Department of Forensic Medicine and Science, University of Glasgow, Scotland.
FAU - Allen, D L
AU  - Allen DL
FAU - Scott, K S
AU  - Scott KS
FAU - Oliver, J S
AU  - Oliver JS
FAU - Ditton, J
AU  - Ditton J
FAU - Smith, I D
AU  - Smith ID
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Forensic Sci
JT  - Journal of forensic sciences
JID - 0375370
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Hallucinogens)
RN  - 44RAL3456C (Methamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Central Nervous System Stimulants/*analysis
MH  - False Negative Reactions
MH  - False Positive Reactions
MH  - Female
MH  - Forensic Medicine
MH  - Gas Chromatography-Mass Spectrometry
MH  - Hair/*chemistry
MH  - Hallucinogens/*analysis
MH  - Humans
MH  - Male
MH  - Methamphetamine/*analysis
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*analysis
MH  - Reproducibility of Results
MH  - *Substance-Related Disorders
EDAT- 2000/04/27 09:00
MHDA- 2000/06/17 09:00
CRDT- 2000/04/27 09:00
PHST- 2000/04/27 09:00 [pubmed]
PHST- 2000/06/17 09:00 [medline]
PHST- 2000/04/27 09:00 [entrez]
PST - ppublish
SO  - J Forensic Sci. 2000 Mar;45(2):400-6.