PMID- 10787008
OWN - NLM
STAT- MEDLINE
DCOM- 20000608
LR  - 20231213
IS  - 0961-2033 (Print)
IS  - 0961-2033 (Linking)
VI  - 9
IP  - 2
DP  - 2000
TI  - ANA negative systemic lupus erythematosus sera revisited serologically.
PG  - 116-9
AB  - OBJECTIVE: To better define the serology of a panel of sera from patients with a 
      clinical diagnosis of systemic lupus erythematosus (SLE) or subacute cutaneous 
      lupus erythematosus (SCLE) with a negative antinuclear antibody (ANA) test on 
      mouse liver. METHODS: Sensitive ELISA methods for anti-Ro/SSA, anti-La/SSB, and 
      anti-U1RNP were applied to a panel of 76 sera with either SLE or SCLE and a 
      negative ANA test on mouse liver. RESULTS: These sera had previously been shown 
      to have a high prevalence of anti-Ro/SSA (68%) and anti-La/SSB (27%) precipitins 
      respectively. None had precipitins to U1RNP or Sm. ELISA methodology revealed 
      that all of the sera 76/76 (100%) had elevated levels (> mean +/- 2 SD of a panel 
      of 21 normal sera) of anti-Ro/SSA, 36/76 (46%) had elevated levels of 
      anti-La/SSB, and 27 of 76 (35%) had elevated levels of anti-U1RNP. CONCLUSION: 
      The subset of patients with SLE and SCLE with a negative ANA test on mouse liver 
      almost uniformly have antibodies to the Ro/SSA antigen by a sensitive ELISA. This 
      adds evidence to the idea that this is a more homogeneous disease subset within 
      the spectrum of SLE.
FAU - Reichlin, M
AU  - Reichlin M
AD  - Oklahoma Medical Research Foundation, Oklahoma City 73104, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Autoantibodies)
RN  - 0 (Autoantigens)
RN  - 0 (RNA, Small Cytoplasmic)
RN  - 0 (RO60 protein, human)
RN  - 0 (Ribonucleoproteins)
RN  - 0 (SS-A antigen)
SB  - IM
MH  - Animals
MH  - Antibodies, Antinuclear/*blood
MH  - Autoantibodies/*blood
MH  - Autoantigens/immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Humans
MH  - Lupus Erythematosus, Cutaneous/*blood/*immunology
MH  - Lupus Erythematosus, Systemic/*blood/*immunology
MH  - Mice
MH  - Precipitin Tests
MH  - *RNA, Small Cytoplasmic
MH  - Retrospective Studies
MH  - Ribonucleoproteins/immunology
MH  - Sensitivity and Specificity
MH  - SS-B Antigen
EDAT- 2000/04/29 09:00
MHDA- 2000/06/10 09:00
CRDT- 2000/04/29 09:00
PHST- 2000/04/29 09:00 [pubmed]
PHST- 2000/06/10 09:00 [medline]
PHST- 2000/04/29 09:00 [entrez]
AID - 10.1191/096120300678828091 [doi]
PST - ppublish
SO  - Lupus. 2000;9(2):116-9. doi: 10.1191/096120300678828091.