PMID- 10790287
OWN - NLM
STAT- MEDLINE
DCOM- 20000609
LR  - 20190915
IS  - 0033-7587 (Print)
IS  - 0033-7587 (Linking)
VI  - 153
IP  - 5 Pt 2
DP  - 2000 May
TI  - Developmental profiles of growth-associated protein (Gap43), Ngfb, Bndf and Ntf4 
      mRNA levels in the rat forebrain after exposure to 60 Hz magnetic fields.
PG  - 642-7
AB  - Fischer 344 rats were exposed to 60 Hz magnetic fields (EMFs) during gestation 
      and lactation. Rats received continuous exposure to 2-, 200- or 1000-microT 
      magnetic fields for 18.5 h per day, 7 days a week, or sham exposure (sham 
      controls). During postnatal development, on postnatal days 1, 3, 6, 9, 15 and 20, 
      forebrain tissue from male pups was examined for alterations in mRNA level for 
      developmentally regulated central nervous system-specific proteins. Alterations 
      in these factors during critical periods of development could result in 
      alterations in the final neural network. Gap43 (growth-associated protein 43) 
      mRNA was measured by Northern hybridization as a developmental indicator of 
      axonal growth during the development of the neuron. Between postnatal days 1 and 
      9, detectable levels of Gap43 mRNA displayed a similar pattern across all sham 
      control and exposure groups. In addition to Gap43, mRNA levels for the nervous 
      system-specific growth factors ciliary neurotrophic factor (Cntf), brain-derived 
      neurotrophic factor (Bdnf), beta nerve growth factor (Ngfb), neurotrophin-3 
      (Ntf3), and neurotrophin-4 (Ntf4) were examined by RNase protection assay. While 
      there is public concern for developmental neurotoxicity associated with exposure 
      to EMFs, these data, generated from animals exposed to 2-, 200- or 1000-microT 
      magnetic fields during both gestational and lactational periods of development, 
      suggest that under these conditions no significant alterations in these critical 
      factors for brain development occur.
FAU - Harry, G J
AU  - Harry GJ
AD  - Neurotoxicology Group, National Institute of Environmental Health Sciences, 
      Research Triangle Park, North Carolina 27709, USA.
FAU - Bartenbach, M
AU  - Bartenbach M
FAU - Haines, W
AU  - Haines W
FAU - Bruccoleri, A
AU  - Bruccoleri A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiat Res
JT  - Radiation research
JID - 0401245
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (GAP-43 Protein)
RN  - 0 (Gdnf protein, rat)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotrophin 3)
RN  - 0 (RNA, Messenger)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - EC 3.1.- (Ribonucleases)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Animals, Suckling
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Dose-Response Relationship, Radiation
MH  - Electromagnetic Fields/*adverse effects
MH  - Environmental Exposure/*adverse effects
MH  - Female
MH  - GAP-43 Protein/genetics/*metabolism
MH  - Glial Cell Line-Derived Neurotrophic Factor
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Nerve Growth Factor/genetics/metabolism
MH  - Nerve Growth Factors/genetics/metabolism
MH  - Nerve Tissue Proteins/genetics/metabolism
MH  - Neurotrophin 3/genetics/metabolism
MH  - Prosencephalon/growth & development/metabolism/*radiation effects
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Inbred F344
MH  - Rats, Sprague-Dawley
MH  - Ribonucleases/metabolism
EDAT- 2000/05/02 09:00
MHDA- 2000/06/17 09:00
CRDT- 2000/05/02 09:00
PHST- 2000/05/02 09:00 [pubmed]
PHST- 2000/06/17 09:00 [medline]
PHST- 2000/05/02 09:00 [entrez]
AID - 10.1667/0033-7587(2000)153[0642:dpogap]2.0.co;2 [doi]
PST - ppublish
SO  - Radiat Res. 2000 May;153(5 Pt 2):642-7. doi: 
      10.1667/0033-7587(2000)153[0642:dpogap]2.0.co;2.