PMID- 10791100
OWN - NLM
STAT- MEDLINE
DCOM- 20000605
LR  - 20061115
IS  - 0009-918X (Print)
IS  - 0009-918X (Linking)
VI  - 39
IP  - 12
DP  - 1999 Dec
TI  - [Microcirculatory derangement and apoptosis in ischemia-reperfusion injury].
PG  - 1291-4
AB  - This study was undertaken to clarify the involvement of microcirculatory failure 
      and apoptosis in the pathophysiology of cerebral ischemia using ICAM-1 knockout 
      mice (K/O) and BCL-2 transgenic mice, respectively. In both permanent and 
      transient focal ischemia, infarcted size of cerebral cortex in ICAM-1 K/O mice 
      was significantly smaller than that in wild type mice. Microcirucaltaory 
      disturbance in the cerebral cortex after permanent and transient focal ischemia 
      was mitigated in ICAM-1 K/O mice compared with that in wild type mice. However, 
      the number of granulocytes in the infarcted tissue was similar between K/O and 
      wild mice, and neutrophil depletion in K/O mice showed further reduction of 
      cortical infarction after transient focal ischemia. In contrast, neuronal 
      overexpression of BCL-2 in mice showed protective effect on selective neuronal 
      death observed in the hippocampus after transient global forebrain ischemia for 
      12 min. The present study supported the notion that (1) microcirculatory 
      disturbance mediated through interaction of ICAM-1 and leukocytes played an 
      important role in expansion of cerebral infarction after focal ischemia and (2) 
      apoptosis inhibited in part by overexpression of BCL-2 was involved in selective 
      neuronal vulnerability after transient global ischemia.
FAU - Kitagawa, K
AU  - Kitagawa K
AD  - Department of Internal Medicine and Therapeutics, Osaka University Graduate 
      School of Medicine, Japan.
FAU - Matumoto, M
AU  - Matumoto M
FAU - Hori, M
AU  - Hori M
FAU - Yanagihara, T
AU  - Yanagihara T
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Rinsho Shinkeigaku
JT  - Rinsho shinkeigaku = Clinical neurology
JID - 0417466
SB  - IM
MH  - Animals
MH  - *Apoptosis
MH  - Cerebral Cortex/blood supply
MH  - Cerebrovascular Circulation/*physiology
MH  - Hippocampus/pathology
MH  - Mice
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - Microcirculation/*physiology
MH  - Reperfusion Injury/*pathology/*physiopathology
EDAT- 2000/05/03 09:00
MHDA- 2000/06/10 09:00
CRDT- 2000/05/03 09:00
PHST- 2000/05/03 09:00 [pubmed]
PHST- 2000/06/10 09:00 [medline]
PHST- 2000/05/03 09:00 [entrez]
PST - ppublish
SO  - Rinsho Shinkeigaku. 1999 Dec;39(12):1291-4.