PMID- 10792159
OWN - NLM
STAT- MEDLINE
DCOM- 20000608
LR  - 20220311
IS  - 1464-4096 (Print)
IS  - 1464-4096 (Linking)
VI  - 85
IP  - 7
DP  - 2000 May
TI  - Lymphadenectomy in patients with transitional cell carcinoma of the urinary 
      bladder; significance for staging and prognosis.
PG  - 817-23
AB  - OBJECTIVE: To determine the need to standardize the number and location of lymph 
      nodes to be removed during radical cystectomy in patients with invasive bladder 
      carcinoma. PATIENTS AND METHODS: The pelvic lymph nodes from 447 patients (mean 
      age 62.8 years) who underwent radical cystectomy between 1986 and 1997 were 
      evaluated. The number of lymph nodes was correlated with the depth of invasion of 
      the primary tumour (pT), occurrence of nodal metastases, clinical outcome, the 
      operating surgeons and the pathologists dissecting the nodes. RESULTS: The 
      clinical follow-up was available for 302 patients (mean follow-up 38.7 months). 
      The mean (range) number of lymph nodes removed was 14.7 (1-46). The number of 
      lymph nodes removed varied significantly among different surgeons but not among 
      pathologists. In pT3 and pT4 tumours, a more extended lymphadenectomy (>/= 16 
      lymph nodes) correlated with a higher percentage of patients with documented 
      nodal metastases. There was a significant correlation between the number of lymph 
      nodes removed and the tumour-free 5-year survival in patients with pT1, pT2 or 
      pT3 tumours, and in patients with 1-5 positive lymph nodes (P < 0.01). 
      CONCLUSION: Extensive lymphadenectomy significantly improves the prognosis of 
      patients with invasive bladder cancer and represents a potentially curative 
      procedure in patients with nodal metastases, including micrometastases that may 
      escape detection during routine histopathological evaluation. The results 
      indicate the need for a standardized lymph node dissection.
FAU - Leissner, J
AU  - Leissner J
AD  - Departments of Urology and Pathology, Johannes Gutenberg University, Mainz, 
      Germany.
FAU - Hohenfellner, R
AU  - Hohenfellner R
FAU - Thuroff, J W
AU  - Thuroff JW
FAU - Wolf, H K
AU  - Wolf HK
LA  - eng
PT  - Journal Article
PL  - England
TA  - BJU Int
JT  - BJU international
JID - 100886721
SB  - IM
MH  - Carcinoma, Transitional Cell/pathology/*surgery
MH  - Cystectomy/methods
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Lymph Node Excision/*methods
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging/methods
MH  - Pelvis
MH  - Prognosis
MH  - Urinary Bladder Neoplasms/pathology/*surgery
EDAT- 2000/05/03 09:00
MHDA- 2000/06/10 09:00
CRDT- 2000/05/03 09:00
PHST- 2000/05/03 09:00 [pubmed]
PHST- 2000/06/10 09:00 [medline]
PHST- 2000/05/03 09:00 [entrez]
AID - bju614 [pii]
AID - 10.1046/j.1464-410x.2000.00614.x [doi]
PST - ppublish
SO  - BJU Int. 2000 May;85(7):817-23. doi: 10.1046/j.1464-410x.2000.00614.x.