PMID- 10794118
OWN - NLM
STAT- MEDLINE
DCOM- 20000629
LR  - 20061115
IS  - 0192-415X (Print)
IS  - 0192-415X (Linking)
VI  - 28
IP  - 1
DP  - 2000
TI  - Inhibition of mast cell-mediated anaphylaxis by sochungryong-tang.
PG  - 69-76
AB  - According to traditional Asian philosophy, sochungryong-tang (S-Tang) is a 
      prescription for treating exterior syndrome. In this study, we investigated the 
      effect of S-Tang on mast cell-mediated anaphylaxis. S-Tang completely inhibited 
      compound 48/80-induced systemic anaphylactic shock at a dose of 100 mg/kg. When 
      S-Tang was given as pretreatment at concentrations ranging from 1 to 1000 mg/kg, 
      the serum histamine levels induced by compound 48/80 were reduced in a 
      dose-dependent manner. S-Tang inhibited the local anaphylaxis activated by 
      anti-dinitrophenyl (DNP) IgE antibody, and also inhibited the histamine release 
      from the rat peritoneal mast cells by compound 48/80 or anti-DNP IgE. These 
      results indicate that S-Tang may contain substances with actions that inhibit 
      mast cell degranulation.
FAU - Kim, H M
AU  - Kim HM
AD  - Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, 
      Iksan-city, Chonbuk, South Korea.
FAU - Yoon, G S
AU  - Yoon GS
FAU - Seo, J U
AU  - Seo JU
FAU - Moon, G
AU  - Moon G
FAU - Kim, H R
AU  - Kim HR
FAU - Shin, T Y
AU  - Shin TY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Singapore
TA  - Am J Chin Med
JT  - The American journal of Chinese medicine
JID - 7901431
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Anaphylaxis/immunology/*prevention & control
MH  - Animals
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Histamine Release/drug effects
MH  - Humans
MH  - Korea
MH  - Mast Cells/*drug effects/immunology/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Passive Cutaneous Anaphylaxis/drug effects
MH  - Rats
MH  - Rats, Wistar
EDAT- 2000/05/04 09:00
MHDA- 2000/07/06 11:00
CRDT- 2000/05/04 09:00
PHST- 2000/05/04 09:00 [pubmed]
PHST- 2000/07/06 11:00 [medline]
PHST- 2000/05/04 09:00 [entrez]
AID - S0192415X0000009X [pii]
AID - 10.1142/S0192415X0000009X [doi]
PST - ppublish
SO  - Am J Chin Med. 2000;28(1):69-76. doi: 10.1142/S0192415X0000009X.